miRandola 2017: a curated knowledge base of non-invasive biomarkers

Francesco Russo; Sebastiano Di Bella; Federica Vannini; Gabriele Berti; Flavia Scoyni; Helen V Cook; Alberto Santos; Giovanni Nigita; Vincenzo Bonnici; Alessandro Laganà; Filippo Geraci; Alfredo Pulvirenti; Rosalba Giugno; Federico De Masi; Kirstine Belling; Lars J Jensen; Søren Brunak; Marco Pellegrini; Alfredo Ferro

doi:10.1093/nar/gkx854

miRandola 2017: a curated knowledge base of non-invasive biomarkers

Francesco Russo, Sebastiano Di Bella, Federica Vannini, Gabriele Berti, Flavia Scoyni, Helen V Cook, Alberto Santos, Giovanni Nigita, Vincenzo Bonnici, Alessandro Laganà, Filippo Geraci, Alfredo Pulvirenti, Rosalba Giugno, Federico De Masi, Kirstine Belling, Lars J Jensen, Søren Brunak, Marco Pellegrini, Alfredo Ferro

Disease Systems Biology Program

31 Citations (Scopus)

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Abstract

miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases. Data are manually curated from 314 articles that describe miRNAs, long non-coding RNAs and circular RNAs. Fourteen organisms are now included in the database, and associations of ncRNAs with 25 drugs, 47 sample types and 197 diseases. miRandola also classifies extracellular RNAs based on their extracellular form: Argonaute2 protein, exosome, microvesicle, microparticle, membrane vesicle, high density lipoprotein and circulating. We also implemented a new web interface to improve the user experience.

Original language	English
Journal	Nucleic Acids Research
Volume	46
Issue number	D1
Pages (from-to)	D354-D359
Number of pages	6
ISSN	0305-1048
DOIs	https://doi.org/10.1093/nar/gkx854
Publication status	Published - 1 Jan 2018

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miRandola 2017: a curated knowledge base of non-invasive biomarkersFinal published version, 1.67 MBLicence: CC BY-NC

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Russo, F., Di Bella, S., Vannini, F., Berti, G., Scoyni, F., Cook, H. V., Santos, A., Nigita, G., Bonnici, V., Laganà, A., Geraci, F., Pulvirenti, A., Giugno, R., De Masi, F., Belling, K., Jensen, L. J., Brunak, S., Pellegrini, M., & Ferro, A. (2018). miRandola 2017: a curated knowledge base of non-invasive biomarkers. Nucleic Acids Research, 46(D1), D354-D359. https://doi.org/10.1093/nar/gkx854

Russo, F, Di Bella, S, Vannini, F, Berti, G, Scoyni, F, Cook, HV, Santos, A, Nigita, G, Bonnici, V, Laganà, A, Geraci, F, Pulvirenti, A, Giugno, R, De Masi, F, Belling, K , Jensen, LJ , Brunak, S, Pellegrini, M & Ferro, A 2018, 'miRandola 2017: a curated knowledge base of non-invasive biomarkers', Nucleic Acids Research, vol. 46, no. D1, pp. D354-D359. https://doi.org/10.1093/nar/gkx854

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title = "miRandola 2017: a curated knowledge base of non-invasive biomarkers",

abstract = "miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases. Data are manually curated from 314 articles that describe miRNAs, long non-coding RNAs and circular RNAs. Fourteen organisms are now included in the database, and associations of ncRNAs with 25 drugs, 47 sample types and 197 diseases. miRandola also classifies extracellular RNAs based on their extracellular form: Argonaute2 protein, exosome, microvesicle, microparticle, membrane vesicle, high density lipoprotein and circulating. We also implemented a new web interface to improve the user experience.",

author = "Francesco Russo and {Di Bella}, Sebastiano and Federica Vannini and Gabriele Berti and Flavia Scoyni and Cook, {Helen V} and Alberto Santos and Giovanni Nigita and Vincenzo Bonnici and Alessandro Lagan{\`a} and Filippo Geraci and Alfredo Pulvirenti and Rosalba Giugno and {De Masi}, Federico and Kirstine Belling and Jensen, {Lars J} and S{\o}ren Brunak and Marco Pellegrini and Alfredo Ferro",

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AU - Russo, Francesco

AU - Di Bella, Sebastiano

AU - Vannini, Federica

AU - Berti, Gabriele

AU - Scoyni, Flavia

AU - Cook, Helen V

AU - Santos, Alberto

AU - Nigita, Giovanni

AU - Bonnici, Vincenzo

AU - Laganà, Alessandro

AU - Geraci, Filippo

AU - Pulvirenti, Alfredo

AU - Giugno, Rosalba

AU - De Masi, Federico

AU - Belling, Kirstine

AU - Jensen, Lars J

AU - Brunak, Søren

AU - Pellegrini, Marco

AU - Ferro, Alfredo

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N2 - miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases. Data are manually curated from 314 articles that describe miRNAs, long non-coding RNAs and circular RNAs. Fourteen organisms are now included in the database, and associations of ncRNAs with 25 drugs, 47 sample types and 197 diseases. miRandola also classifies extracellular RNAs based on their extracellular form: Argonaute2 protein, exosome, microvesicle, microparticle, membrane vesicle, high density lipoprotein and circulating. We also implemented a new web interface to improve the user experience.

AB - miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases. Data are manually curated from 314 articles that describe miRNAs, long non-coding RNAs and circular RNAs. Fourteen organisms are now included in the database, and associations of ncRNAs with 25 drugs, 47 sample types and 197 diseases. miRandola also classifies extracellular RNAs based on their extracellular form: Argonaute2 protein, exosome, microvesicle, microparticle, membrane vesicle, high density lipoprotein and circulating. We also implemented a new web interface to improve the user experience.

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DO - 10.1093/nar/gkx854

M3 - Journal article

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SP - D354-D359

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - D1

ER -

miRandola 2017: a curated knowledge base of non-invasive biomarkers

Abstract

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