miRandola 2017: a curated knowledge base of non-invasive biomarkers

TY - JOUR

T1 - miRandola 2017

T2 - a curated knowledge base of non-invasive biomarkers

AU - Russo, Francesco

AU - Di Bella, Sebastiano

AU - Vannini, Federica

AU - Berti, Gabriele

AU - Scoyni, Flavia

AU - Cook, Helen V

AU - Santos, Alberto

AU - Nigita, Giovanni

AU - Bonnici, Vincenzo

AU - Laganà, Alessandro

AU - Geraci, Filippo

AU - Pulvirenti, Alfredo

AU - Giugno, Rosalba

AU - De Masi, Federico

AU - Belling, Kirstine

AU - Jensen, Lars J

AU - Brunak, Søren

AU - Pellegrini, Marco

AU - Ferro, Alfredo

N1 - © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases. Data are manually curated from 314 articles that describe miRNAs, long non-coding RNAs and circular RNAs. Fourteen organisms are now included in the database, and associations of ncRNAs with 25 drugs, 47 sample types and 197 diseases. miRandola also classifies extracellular RNAs based on their extracellular form: Argonaute2 protein, exosome, microvesicle, microparticle, membrane vesicle, high density lipoprotein and circulating. We also implemented a new web interface to improve the user experience.

AB - miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases. Data are manually curated from 314 articles that describe miRNAs, long non-coding RNAs and circular RNAs. Fourteen organisms are now included in the database, and associations of ncRNAs with 25 drugs, 47 sample types and 197 diseases. miRandola also classifies extracellular RNAs based on their extracellular form: Argonaute2 protein, exosome, microvesicle, microparticle, membrane vesicle, high density lipoprotein and circulating. We also implemented a new web interface to improve the user experience.

U2 - 10.1093/nar/gkx854

DO - 10.1093/nar/gkx854

M3 - Journal article

C2 - 29036351

SN - 0305-1048

VL - 46

SP - D354-D359

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - D1

ER -