Microwave-assisted solid-phase Ugi four-component condensations

Andreas M L Hoel; John Nielsen

doi:10.1016/S0040-4039(99)00616-4

Microwave-assisted solid-phase Ugi four-component condensations

Andreas M L Hoel, John Nielsen^*

^*Corresponding author for this work

91 Citations (Scopus)

Abstract

An 18-member library was constructed from 2 isocyanides, 3 aldehydes and 3 carboxylic acids via microwave-assisted solid-phase Ugi reactions on TentaGel S RAM. Products of high purity were obtained in moderate to excellent yields after reaction times of 5 minutes or less (irradiation at 60W).

Original language	English
Journal	Tetrahedron Letters
Volume	40
Issue number	20
Pages (from-to)	3941-3944
Number of pages	4
ISSN	0040-4039
DOIs	https://doi.org/10.1016/S0040-4039(99)00616-4
Publication status	Published - 14 May 1999

Keywords

Combinatorial chemistry
Microwave heating
Solid-Phase synthesis
Ugi-Passerini reactions

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title = "Microwave-assisted solid-phase Ugi four-component condensations",

abstract = "An 18-member library was constructed from 2 isocyanides, 3 aldehydes and 3 carboxylic acids via microwave-assisted solid-phase Ugi reactions on TentaGel S RAM. Products of high purity were obtained in moderate to excellent yields after reaction times of 5 minutes or less (irradiation at 60W).",

keywords = "Combinatorial chemistry, Microwave heating, Solid-Phase synthesis, Ugi-Passerini reactions",

author = "Hoel, {Andreas M L} and John Nielsen",

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AU - Hoel, Andreas M L

AU - Nielsen, John

PY - 1999/5/14

Y1 - 1999/5/14

N2 - An 18-member library was constructed from 2 isocyanides, 3 aldehydes and 3 carboxylic acids via microwave-assisted solid-phase Ugi reactions on TentaGel S RAM. Products of high purity were obtained in moderate to excellent yields after reaction times of 5 minutes or less (irradiation at 60W).

AB - An 18-member library was constructed from 2 isocyanides, 3 aldehydes and 3 carboxylic acids via microwave-assisted solid-phase Ugi reactions on TentaGel S RAM. Products of high purity were obtained in moderate to excellent yields after reaction times of 5 minutes or less (irradiation at 60W).

KW - Combinatorial chemistry

KW - Microwave heating

KW - Solid-Phase synthesis

KW - Ugi-Passerini reactions

U2 - 10.1016/S0040-4039(99)00616-4

DO - 10.1016/S0040-4039(99)00616-4

M3 - Journal article

AN - SCOPUS:0033553530

SN - 0040-4039

VL - 40

SP - 3941

EP - 3944

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 20

ER -

Microwave-assisted solid-phase Ugi four-component condensations

Abstract

Keywords

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