Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Ahmed R Hassan; Salah M El-Kousy; Sayed A El-Toumy; Karla Frydenvang; Truong Thanh Tung; Jesper Olsen; John Nielsen; Søren Brøgger Christensen

doi:10.1021/acs.jnatprod.7b00106

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Ahmed R Hassan, Salah M El-Kousy, Sayed A El-Toumy, Karla Frydenvang, Truong Thanh Tung, Jesper Olsen, John Nielsen, Søren Brøgger Christensen

2 Citationer (Scopus)

Abstract

A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

Originalsprog	Engelsk
Tidsskrift	Journal of Natural Products
Vol/bind	80
Sider (fra-til)	2830-2834
Antal sider	5
ISSN	0163-3864
DOI	https://doi.org/10.1021/acs.jnatprod.7b00106
Status	Udgivet - 27 okt. 2017

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10.1021/acs.jnatprod.7b00106

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title = "Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula",

abstract = "A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.",

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author = "Hassan, {Ahmed R} and El-Kousy, {Salah M} and El-Toumy, {Sayed A} and Karla Frydenvang and Tung, {Truong Thanh} and Jesper Olsen and John Nielsen and Christensen, {S{\o}ren Br{\o}gger}",

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doi = "10.1021/acs.jnatprod.7b00106",

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AU - Hassan, Ahmed R

AU - El-Kousy, Salah M

AU - El-Toumy, Sayed A

AU - Frydenvang, Karla

AU - Tung, Truong Thanh

AU - Olsen, Jesper

AU - Nielsen, John

AU - Christensen, Søren Brøgger

PY - 2017/10/27

Y1 - 2017/10/27

N2 - A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

AB - A phytochemical investigation of Seidlitzia rosmarinus collected along the shoreline of the Gulf of Aqaba in the remote southern desert region of the Sinai peninsula has revealed the presence of the registered drug metformin (4). However, analysis of the (14)C content revealed the drug to be an anthropogenic contaminant. Consequently, natural product researchers should be aware that compounds isolated from plants might originate from environmental contamination rather than biosynthesis. The new natural product N-(4-hydroxyphenylethyl)-α-chloroferuloylamide was isolated as a mixture of the E and Z isomers along with a number of other well-established secondary metabolites.

KW - Journal Article

U2 - 10.1021/acs.jnatprod.7b00106

DO - 10.1021/acs.jnatprod.7b00106

M3 - Journal article

C2 - 28930456

SN - 0163-3864

VL - 80

SP - 2830

EP - 2834

JO - Journal of Natural Products

JF - Journal of Natural Products

ER -

Metformin, an Anthropogenic Contaminant of Seidlitzia rosmarinus Collected in a Desert Region near the Gulf of Aqaba, Sinai Peninsula

Abstract

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