Mechanisms of oncogenic cell competition-Paths of victory

Alejandro Gutiérrez-Martínez; Wei Qi Guinevere Sew; Maria Molano-Fernández; Maria Carretero-Junquera; Héctor Herranz

doi:10.1016/j.semcancer.2019.05.015

Mechanisms of oncogenic cell competition-Paths of victory

Alejandro Gutiérrez-Martínez, Wei Qi Guinevere Sew, Maria Molano-Fernández, Maria Carretero-Junquera, Héctor Herranz

Morphogenesis and Differentiation Program

7 Citations (Scopus)

Abstract

Cancer is a multistep process. In the early phases of this disease, mutations in oncogenes and tumor suppressors are thought to promote clonal expansion. These mutations can increase cell competitiveness, allowing tumor cells to grow within the tissue by eliminating wild type host cells. Recent studies have shown that cell competition can also function in later phases of cancer. Here, we examine the existing evidence linking cell competition and tumorigenesis. We focus on the mechanisms underlying cell competition and their contribution to disease pathogenesis.

Original language	English
Journal	Seminars in Cancer Biology
ISSN	1044-579X
DOIs	https://doi.org/10.1016/j.semcancer.2019.05.015
Publication status	Published - Jun 2020

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10.1016/j.semcancer.2019.05.015

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title = "Mechanisms of oncogenic cell competition-Paths of victory",

abstract = "Cancer is a multistep process. In the early phases of this disease, mutations in oncogenes and tumor suppressors are thought to promote clonal expansion. These mutations can increase cell competitiveness, allowing tumor cells to grow within the tissue by eliminating wild type host cells. Recent studies have shown that cell competition can also function in later phases of cancer. Here, we examine the existing evidence linking cell competition and tumorigenesis. We focus on the mechanisms underlying cell competition and their contribution to disease pathogenesis.",

author = "Alejandro Guti{\'e}rrez-Mart{\'i}nez and Sew, {Wei Qi Guinevere} and Maria Molano-Fern{\'a}ndez and Maria Carretero-Junquera and H{\'e}ctor Herranz",

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AU - Gutiérrez-Martínez, Alejandro

AU - Sew, Wei Qi Guinevere

AU - Molano-Fernández, Maria

AU - Carretero-Junquera, Maria

AU - Herranz, Héctor

PY - 2020/6

Y1 - 2020/6

N2 - Cancer is a multistep process. In the early phases of this disease, mutations in oncogenes and tumor suppressors are thought to promote clonal expansion. These mutations can increase cell competitiveness, allowing tumor cells to grow within the tissue by eliminating wild type host cells. Recent studies have shown that cell competition can also function in later phases of cancer. Here, we examine the existing evidence linking cell competition and tumorigenesis. We focus on the mechanisms underlying cell competition and their contribution to disease pathogenesis.

AB - Cancer is a multistep process. In the early phases of this disease, mutations in oncogenes and tumor suppressors are thought to promote clonal expansion. These mutations can increase cell competitiveness, allowing tumor cells to grow within the tissue by eliminating wild type host cells. Recent studies have shown that cell competition can also function in later phases of cancer. Here, we examine the existing evidence linking cell competition and tumorigenesis. We focus on the mechanisms underlying cell competition and their contribution to disease pathogenesis.

U2 - 10.1016/j.semcancer.2019.05.015

DO - 10.1016/j.semcancer.2019.05.015

M3 - Review

C2 - 31128299

SN - 1044-579X

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

Mechanisms of oncogenic cell competition-Paths of victory

Abstract

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