TY - JOUR
T1 - Mechanisms of oncogenic cell competition-Paths of victory
AU - Gutiérrez-Martínez, Alejandro
AU - Sew, Wei Qi Guinevere
AU - Molano-Fernández, Maria
AU - Carretero-Junquera, Maria
AU - Herranz, Héctor
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Cancer is a multistep process. In the early phases of this disease, mutations in oncogenes and tumor suppressors are thought to promote clonal expansion. These mutations can increase cell competitiveness, allowing tumor cells to grow within the tissue by eliminating wild type host cells. Recent studies have shown that cell competition can also function in later phases of cancer. Here, we examine the existing evidence linking cell competition and tumorigenesis. We focus on the mechanisms underlying cell competition and their contribution to disease pathogenesis.
AB - Cancer is a multistep process. In the early phases of this disease, mutations in oncogenes and tumor suppressors are thought to promote clonal expansion. These mutations can increase cell competitiveness, allowing tumor cells to grow within the tissue by eliminating wild type host cells. Recent studies have shown that cell competition can also function in later phases of cancer. Here, we examine the existing evidence linking cell competition and tumorigenesis. We focus on the mechanisms underlying cell competition and their contribution to disease pathogenesis.
U2 - 10.1016/j.semcancer.2019.05.015
DO - 10.1016/j.semcancer.2019.05.015
M3 - Review
C2 - 31128299
SN - 1044-579X
JO - Seminars in Cancer Biology
JF - Seminars in Cancer Biology
ER -
