Abstract
mRNA localization, and translation that is regulated spatially and temporally, are key mechanisms in the execution of polarized developmental programs. For over two decades, the Drosophila oocyte has served as a valuable model to study these mechanisms. Genetic and biochemical studies in flies have greatly contributed to the identification and understanding of factors that govern RNA localization and translational control. Embryonic axis formation is mediated through the subcellular localization and precise translational regulation of four key determinant mRNAs during oogenesis encoded by oskar, bicoid, gurken and nanos. In this review we aim to summarize recent insights into the mechanisms governing the asymmetric distribution and translation of these mRNAs.
| Original language | English |
|---|---|
| Journal | Fly |
| Volume | 3 |
| Issue number | 1 |
| Pages (from-to) | 15-28 |
| Number of pages | 14 |
| ISSN | 1933-6934 |
| Publication status | Published - 3 Feb 2009 |
| Externally published | Yes |
Keywords
- Animals
- Biological Transport, Active
- Cell Polarity
- Drosophila
- Drosophila Proteins
- Female
- Genes, Insect
- Homeodomain Proteins
- Microtubules
- Models, Biological
- Oogenesis
- Protein Biosynthesis
- RNA, Messenger
- RNA-Binding Proteins
- Trans-Activators
- Transforming Growth Factor alpha