Localization, anchoring and translational control of oskar, gurken, bicoid and nanos mRNA during Drosophila oogenesis

Jan-Michael Kugler; Paul Lasko

Localization, anchoring and translational control of oskar, gurken, bicoid and nanos mRNA during Drosophila oogenesis

100 Citationer (Scopus)

Abstract

mRNA localization, and translation that is regulated spatially and temporally, are key mechanisms in the execution of polarized developmental programs. For over two decades, the Drosophila oocyte has served as a valuable model to study these mechanisms. Genetic and biochemical studies in flies have greatly contributed to the identification and understanding of factors that govern RNA localization and translational control. Embryonic axis formation is mediated through the subcellular localization and precise translational regulation of four key determinant mRNAs during oogenesis encoded by oskar, bicoid, gurken and nanos. In this review we aim to summarize recent insights into the mechanisms governing the asymmetric distribution and translation of these mRNAs.

Originalsprog	Engelsk
Tidsskrift	Fly
Vol/bind	3
Udgave nummer	1
Sider (fra-til)	15-28
Antal sider	14
ISSN	1933-6934
Status	Udgivet - 3 feb. 2009
Udgivet eksternt	Ja

Citationsformater

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abstract = "mRNA localization, and translation that is regulated spatially and temporally, are key mechanisms in the execution of polarized developmental programs. For over two decades, the Drosophila oocyte has served as a valuable model to study these mechanisms. Genetic and biochemical studies in flies have greatly contributed to the identification and understanding of factors that govern RNA localization and translational control. Embryonic axis formation is mediated through the subcellular localization and precise translational regulation of four key determinant mRNAs during oogenesis encoded by oskar, bicoid, gurken and nanos. In this review we aim to summarize recent insights into the mechanisms governing the asymmetric distribution and translation of these mRNAs.",

keywords = "Animals, Biological Transport, Active, Cell Polarity, Drosophila, Drosophila Proteins, Female, Genes, Insect, Homeodomain Proteins, Microtubules, Models, Biological, Oogenesis, Protein Biosynthesis, RNA, Messenger, RNA-Binding Proteins, Trans-Activators, Transforming Growth Factor alpha",

author = "Jan-Michael Kugler and Paul Lasko",

year = "2009",

month = feb,

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language = "English",

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journal = "Fly",

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TY - JOUR

T1 - Localization, anchoring and translational control of oskar, gurken, bicoid and nanos mRNA during Drosophila oogenesis

AU - Kugler, Jan-Michael

AU - Lasko, Paul

PY - 2009/2/3

Y1 - 2009/2/3

N2 - mRNA localization, and translation that is regulated spatially and temporally, are key mechanisms in the execution of polarized developmental programs. For over two decades, the Drosophila oocyte has served as a valuable model to study these mechanisms. Genetic and biochemical studies in flies have greatly contributed to the identification and understanding of factors that govern RNA localization and translational control. Embryonic axis formation is mediated through the subcellular localization and precise translational regulation of four key determinant mRNAs during oogenesis encoded by oskar, bicoid, gurken and nanos. In this review we aim to summarize recent insights into the mechanisms governing the asymmetric distribution and translation of these mRNAs.

AB - mRNA localization, and translation that is regulated spatially and temporally, are key mechanisms in the execution of polarized developmental programs. For over two decades, the Drosophila oocyte has served as a valuable model to study these mechanisms. Genetic and biochemical studies in flies have greatly contributed to the identification and understanding of factors that govern RNA localization and translational control. Embryonic axis formation is mediated through the subcellular localization and precise translational regulation of four key determinant mRNAs during oogenesis encoded by oskar, bicoid, gurken and nanos. In this review we aim to summarize recent insights into the mechanisms governing the asymmetric distribution and translation of these mRNAs.

KW - Animals

KW - Biological Transport, Active

KW - Cell Polarity

KW - Drosophila

KW - Drosophila Proteins

KW - Female

KW - Genes, Insect

KW - Homeodomain Proteins

KW - Microtubules

KW - Models, Biological

KW - Oogenesis

KW - Protein Biosynthesis

KW - RNA, Messenger

KW - RNA-Binding Proteins

KW - Trans-Activators

KW - Transforming Growth Factor alpha

M3 - Journal article

C2 - 19182536

SN - 1933-6934

VL - 3

SP - 15

EP - 28

JO - Fly

JF - Fly

IS - 1

ER -

Localization, anchoring and translational control of oskar, gurken, bicoid and nanos mRNA during Drosophila oogenesis

Abstract

Fingeraftryk

Citationsformater