Research output per year
Research output per year
Personal profile
Primary fields of research
I am broadly interested in the molecular and cellular mechanisms that leads to malignant transformation of cancer cells. I am using an invertebrate model organism – the fruit fly Drosophila – as a discovery platform to identify novel genes involved in metastasis development. I am using mammalian cell culture models to explore whether the function of candidate genes may be conserved and hence potentially relevant to human cancers.
Current research
Currently, I am investigating ubiquitin-dependent regulation of a well-known tumor suppressor gene by a de-ubiquitinating enzyme. Moreover, I am investigating a novel metabolic enzyme whose depletion causes cancer-like phenotypes both in the fly and in cultured human cells.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- Faculty of Health and Medical Sciences
- Translational Cancer Research
- Genetic Models of Metastasis
- Cancer Cell Metabolism
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Dive into the research topics where Jan-Michael Kugler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Regulation of tumor immune evasion by the Hippo effector TAZ
Ralbovska, A. & Kugler, J. M., 2019, In: Gland Surgery. 8, 4, p. 327-328 2 p.Research output: Contribution to journal › Editorial › peer-review
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Metabolic control of PPAR activity by aldehyde dehydrogenase regulates invasive cell behavior and predicts survival in hepatocellular and renal clear cell carcinoma
Andrejeva, D., Kugler, J. M., Nguyen, H. T., Malmendal, A., Holm, M. L., Toft, B. G., Loya, A. C. & Cohen, S. M., 2018, In: BMC Cancer. 18, 15 p., 1180.Research output: Contribution to journal › Journal article › Research › peer-review
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Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer
Nguyen, T. & Kugler, J., 17 Apr 2018, In: Cancers. 10, 4, 21 p., 121.Research output: Contribution to journal › Review › peer-review
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DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins
Nguyen, T. H., Kugler, J-M. & Cohen, S. M., 6 Jan 2017, In: PLOS ONE. 12, 1, 15 p., e0169587.Research output: Contribution to journal › Journal article › Research › peer-review
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USP21 regulates Hippo pathway activity by mediating MARK protein turnover
Nguyen, T. H., Kugler, J-M., Loya, A. C. & Cohen, S. M., 2017, In: OncoTarget. 8, p. 64095-64105 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Regulation of Pattern Formation and Gene Amplification During Drosophila Oogenesis by the miR-318 microRNA
Ge, W., Deng, Q., Guo, T., Hong, X., Kugler, J-M., Yang, X. & Cohen, S. M., 1 Jan 2015, In: Genetics. 200, 1, p. 255-265 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systematic Study of Drosophila MicroRNA Functions Using a Collection of Targeted Knockout Mutations
Chen, Y-W., Song, S., Weng, R., Verma, P., Kugler, J-M., Buescher, M., Rouam, S. & Cohen, S. M., 22 Dec 2014, In: Developmental Cell. 31, 6, p. 784-800 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster
Kugler, J-M., Chen, Y-W., Weng, R. & Cohen, S. M., Sept 2013, In: G3: Genes, Genomes, Genetics (Bethesda). 3, 9, p. 1573-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review