Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study

Pernille Koefoed Theil; Line Kessel; Torben Hansen; Henrik Lund-Andersen; Oluf Pedersen; Michael Larsen

doi:10.1080/02713680600850971

Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study

Pernille Koefoed Theil, Line Kessel, Torben Hansen, Henrik Lund-Andersen, Oluf Pedersen, Michael Larsen

Department of Clinical Medicine

5 Citations (Scopus)

Abstract

The fluorescence of the lens has the characteristics of a life-long cumulative index of glycemia, and it is elevated in patients with diabetes in proportion to the duration of diabetes and the level of glycemia. Consequently, lens fluorometry should be capable of providing an estimate of prediagnostic disease duration when patients are diagnosed with type 2 diabetes. Among euglycemic subjects, first-degree relatives of patients with type 2 diabetes tend to have higher glycemia levels than subjects who are unrelated to diabetes patients. They should therefore also have the higher lens fluorescence values.

Original language	English
Journal	Current Eye Research
Volume	31
Issue number	9
Pages (from-to)	733-8
Number of pages	6
ISSN	0271-3683
DOIs	https://doi.org/10.1080/02713680600850971
Publication status	Published - 2006

Keywords

Adult
Aged
Aged, 80 and over
Blood Glucose
Diabetes Mellitus, Type 2
Female
Fluorescence
Fluorophotometry
Genetic Predisposition to Disease
Glucose Tolerance Test
Glycemic Index
Humans
Lens, Crystalline
Male
Middle Aged

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/02713680600850971

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title = "Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study",

abstract = "The fluorescence of the lens has the characteristics of a life-long cumulative index of glycemia, and it is elevated in patients with diabetes in proportion to the duration of diabetes and the level of glycemia. Consequently, lens fluorometry should be capable of providing an estimate of prediagnostic disease duration when patients are diagnosed with type 2 diabetes. Among euglycemic subjects, first-degree relatives of patients with type 2 diabetes tend to have higher glycemia levels than subjects who are unrelated to diabetes patients. They should therefore also have the higher lens fluorescence values.",

keywords = "Adult, Aged, Aged, 80 and over, Blood Glucose, Diabetes Mellitus, Type 2, Female, Fluorescence, Fluorophotometry, Genetic Predisposition to Disease, Glucose Tolerance Test, Glycemic Index, Humans, Lens, Crystalline, Male, Middle Aged",

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T1 - Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study

AU - Koefoed Theil, Pernille

AU - Kessel, Line

AU - Hansen, Torben

AU - Lund-Andersen, Henrik

AU - Pedersen, Oluf

AU - Larsen, Michael

PY - 2006

Y1 - 2006

N2 - The fluorescence of the lens has the characteristics of a life-long cumulative index of glycemia, and it is elevated in patients with diabetes in proportion to the duration of diabetes and the level of glycemia. Consequently, lens fluorometry should be capable of providing an estimate of prediagnostic disease duration when patients are diagnosed with type 2 diabetes. Among euglycemic subjects, first-degree relatives of patients with type 2 diabetes tend to have higher glycemia levels than subjects who are unrelated to diabetes patients. They should therefore also have the higher lens fluorescence values.

AB - The fluorescence of the lens has the characteristics of a life-long cumulative index of glycemia, and it is elevated in patients with diabetes in proportion to the duration of diabetes and the level of glycemia. Consequently, lens fluorometry should be capable of providing an estimate of prediagnostic disease duration when patients are diagnosed with type 2 diabetes. Among euglycemic subjects, first-degree relatives of patients with type 2 diabetes tend to have higher glycemia levels than subjects who are unrelated to diabetes patients. They should therefore also have the higher lens fluorescence values.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Blood Glucose

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Fluorescence

KW - Fluorophotometry

KW - Genetic Predisposition to Disease

KW - Glucose Tolerance Test

KW - Glycemic Index

KW - Humans

KW - Lens, Crystalline

KW - Male

KW - Middle Aged

U2 - 10.1080/02713680600850971

DO - 10.1080/02713680600850971

M3 - Journal article

C2 - 16966146

SN - 0271-3683

VL - 31

SP - 733

EP - 738

JO - Current Eye Research

JF - Current Eye Research

IS - 9

ER -

Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study

Abstract

Keywords

UN SDGs

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