Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study

Pernille Koefoed Theil; Line Kessel; Torben Hansen; Henrik Lund-Andersen; Oluf Pedersen; Michael Larsen

doi:10.1080/02713680600850971

Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study

Pernille Koefoed Theil, Line Kessel, Torben Hansen, Henrik Lund-Andersen, Oluf Pedersen, Michael Larsen

Institut for Klinisk Medicin

5 Citationer (Scopus)

Abstract

The fluorescence of the lens has the characteristics of a life-long cumulative index of glycemia, and it is elevated in patients with diabetes in proportion to the duration of diabetes and the level of glycemia. Consequently, lens fluorometry should be capable of providing an estimate of prediagnostic disease duration when patients are diagnosed with type 2 diabetes. Among euglycemic subjects, first-degree relatives of patients with type 2 diabetes tend to have higher glycemia levels than subjects who are unrelated to diabetes patients. They should therefore also have the higher lens fluorescence values.

Originalsprog	Engelsk
Tidsskrift	Current Eye Research
Vol/bind	31
Udgave nummer	9
Sider (fra-til)	733-8
Antal sider	6
ISSN	0271-3683
DOI	https://doi.org/10.1080/02713680600850971
Status	Udgivet - 2006

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@article{78aae775d5844869859be996801d4777,

title = "Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study",

abstract = "The fluorescence of the lens has the characteristics of a life-long cumulative index of glycemia, and it is elevated in patients with diabetes in proportion to the duration of diabetes and the level of glycemia. Consequently, lens fluorometry should be capable of providing an estimate of prediagnostic disease duration when patients are diagnosed with type 2 diabetes. Among euglycemic subjects, first-degree relatives of patients with type 2 diabetes tend to have higher glycemia levels than subjects who are unrelated to diabetes patients. They should therefore also have the higher lens fluorescence values.",

keywords = "Adult, Aged, Aged, 80 and over, Blood Glucose, Diabetes Mellitus, Type 2, Female, Fluorescence, Fluorophotometry, Genetic Predisposition to Disease, Glucose Tolerance Test, Glycemic Index, Humans, Lens, Crystalline, Male, Middle Aged",

author = "{Koefoed Theil}, Pernille and Line Kessel and Torben Hansen and Henrik Lund-Andersen and Oluf Pedersen and Michael Larsen",

year = "2006",

doi = "10.1080/02713680600850971",

language = "English",

volume = "31",

pages = "733--8",

journal = "Current Eye Research",

issn = "0271-3683",

publisher = "Taylor & Francis",

number = "9",

}

TY - JOUR

T1 - Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study

AU - Koefoed Theil, Pernille

AU - Kessel, Line

AU - Hansen, Torben

AU - Lund-Andersen, Henrik

AU - Pedersen, Oluf

AU - Larsen, Michael

PY - 2006

Y1 - 2006

N2 - The fluorescence of the lens has the characteristics of a life-long cumulative index of glycemia, and it is elevated in patients with diabetes in proportion to the duration of diabetes and the level of glycemia. Consequently, lens fluorometry should be capable of providing an estimate of prediagnostic disease duration when patients are diagnosed with type 2 diabetes. Among euglycemic subjects, first-degree relatives of patients with type 2 diabetes tend to have higher glycemia levels than subjects who are unrelated to diabetes patients. They should therefore also have the higher lens fluorescence values.

AB - The fluorescence of the lens has the characteristics of a life-long cumulative index of glycemia, and it is elevated in patients with diabetes in proportion to the duration of diabetes and the level of glycemia. Consequently, lens fluorometry should be capable of providing an estimate of prediagnostic disease duration when patients are diagnosed with type 2 diabetes. Among euglycemic subjects, first-degree relatives of patients with type 2 diabetes tend to have higher glycemia levels than subjects who are unrelated to diabetes patients. They should therefore also have the higher lens fluorescence values.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Blood Glucose

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Fluorescence

KW - Fluorophotometry

KW - Genetic Predisposition to Disease

KW - Glucose Tolerance Test

KW - Glycemic Index

KW - Humans

KW - Lens, Crystalline

KW - Male

KW - Middle Aged

U2 - 10.1080/02713680600850971

DO - 10.1080/02713680600850971

M3 - Journal article

C2 - 16966146

SN - 0271-3683

VL - 31

SP - 733

EP - 738

JO - Current Eye Research

JF - Current Eye Research

IS - 9

ER -

Lens fluorescence in relation to glucose tolerance and genetic predisposition to type 2 diabetes mellitus in a population-based study

Abstract

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