Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria

Anja T R Jensen; Hanne D Zornig; Caecilie Buhmann; Ali Salanti; Kwadwo A Koram; Eleanor M Riley; Thor G Theander; Lars Hviid; Trine Staalsoe

doi:10.1128/IAI.71.7.4193–4196.2003

Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria

Anja T R Jensen, Hanne D Zornig, Caecilie Buhmann, Ali Salanti, Kwadwo A Koram, Eleanor M Riley, Thor G Theander, Lars Hviid, Trine Staalsoe

17 Citations (Scopus)

Abstract

Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.

Original language	English
Journal	Infection and Immunity
Volume	71
Issue number	7
Pages (from-to)	4193-6
Number of pages	3
ISSN	0019-9567
DOIs	https://doi.org/10.1128/IAI.71.7.4193–4196.2003
Publication status	Published - 2003

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10.1128/IAI.71.7.4193–4196.2003

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Jensen, A. T. R., Zornig, H. D., Buhmann, C., Salanti, A., Koram, K. A., Riley, E. M., Theander, T. G., Hviid, L., & Staalsoe, T. (2003). Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria. Infection and Immunity, 71(7), 4193-6. https://doi.org/10.1128/IAI.71.7.4193–4196.2003

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title = "Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria",

abstract = "Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.",

author = "Jensen, {Anja T R} and Zornig, {Hanne D} and Caecilie Buhmann and Ali Salanti and Koram, {Kwadwo A} and Riley, {Eleanor M} and Theander, {Thor G} and Lars Hviid and Trine Staalsoe",

note = "Keywords: Animals; Antibodies, Protozoan; Chondroitin Sulfates; Female; Humans; Immunoglobulin G; Malaria, Falciparum; Male; Parity; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic; Protozoan Proteins; Sex Factors",

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doi = "10.1128/IAI.71.7.4193–4196.2003",

language = "English",

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T1 - Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria

AU - Jensen, Anja T R

AU - Zornig, Hanne D

AU - Buhmann, Caecilie

AU - Salanti, Ali

AU - Koram, Kwadwo A

AU - Riley, Eleanor M

AU - Theander, Thor G

AU - Hviid, Lars

AU - Staalsoe, Trine

N1 - Keywords: Animals; Antibodies, Protozoan; Chondroitin Sulfates; Female; Humans; Immunoglobulin G; Malaria, Falciparum; Male; Parity; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic; Protozoan Proteins; Sex Factors

PY - 2003

Y1 - 2003

N2 - Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.

AB - Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.

U2 - 10.1128/IAI.71.7.4193–4196.2003

DO - 10.1128/IAI.71.7.4193–4196.2003

M3 - Journal article

C2 - 12819117

SN - 0019-9567

VL - 71

SP - 4193

EP - 4196

JO - Infection and Immunity

JF - Infection and Immunity

IS - 7

ER -

Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria

Abstract

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