Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria

TY - JOUR

T1 - Lack of gender-specific antibody recognition of products from domains of a var gene implicated in pregnancy-associated Plasmodium falciparum malaria

AU - Jensen, Anja T R

AU - Zornig, Hanne D

AU - Buhmann, Caecilie

AU - Salanti, Ali

AU - Koram, Kwadwo A

AU - Riley, Eleanor M

AU - Theander, Thor G

AU - Hviid, Lars

AU - Staalsoe, Trine

N1 - Keywords: Animals; Antibodies, Protozoan; Chondroitin Sulfates; Female; Humans; Immunoglobulin G; Malaria, Falciparum; Male; Parity; Plasmodium falciparum; Pregnancy; Pregnancy Complications, Parasitic; Protozoan Proteins; Sex Factors

PY - 2003

Y1 - 2003

N2 - Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.

AB - Gender-specific and parity-dependent acquired antibody recognition is characteristic of variant surface antigens (VSA) expressed by chondroitin sulfate A (CSA)-adherent Plasmodium falciparum involved in pregnancy-associated malaria (PAM). However, antibody recognition of recombinant products of a specific VSA gene (2O2var1) implicated in PAM and transcribed by a CSA-adhering parasite line did not have these characteristics. Furthermore, we could not demonstrate preferential transcription of 2O2var1 in the CSA-adhering line versus the unselected, parental isolate. Our data call for circumspection regarding the molecular identity of the parasite ligand mediating adhesion to CSA in PAM.

U2 - 10.1128/IAI.71.7.4193–4196.2003

DO - 10.1128/IAI.71.7.4193–4196.2003

M3 - Journal article

C2 - 12819117

SN - 0019-9567

VL - 71

SP - 4193

EP - 4196

JO - Infection and Immunity

JF - Infection and Immunity

IS - 7

ER -