Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

Julio E Celis; Pavel Gromov; Irina Gromova; José Manuel Alfonso Moreira; Teresa Cabezón; Noona Ambartsumian; Mariam Grigorian; Eugene Lukanidin; Per Thor Straten; Per Guldberg; Jirina Bartkova; Jiri Bartek; Jiri Lukas; Claudia Lukas; Anne Lykkesfeldt; Marja Jäättelä; Peter Roepstorff; Lars Bolund; Torben Falck Ørntoft; Nils Brünner; Jens Overgaard; Kerstin Sandelin; Mogens Blichert-Toft; Henning Mouridsen; Fritz E Rank

doi:10.1074/mcp.R300007-MCP200

Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

Julio E Celis, Pavel Gromov, Irina Gromova, José Manuel Alfonso Moreira, Teresa Cabezón, Noona Ambartsumian, Mariam Grigorian, Eugene Lukanidin, Per Thor Straten, Per Guldberg, Jirina Bartkova, Jiri Bartek, Jiri Lukas, Claudia Lukas, Anne Lykkesfeldt, Marja Jäättelä, Peter Roepstorff, Lars Bolund, Torben Falck Ørntoft, Nils BrünnerJens Overgaard, Kerstin Sandelin, Mogens Blichert-Toft, Henning Mouridsen, Fritz E Rank

45 Citationer (Scopus)

Abstract

The application of state-of-the-art proteomics and functional genomics technologies to the study of cancer is rapidly shifting toward the analysis of clinically relevant samples derived from patients, as the ultimate aim of translational research is to bring basic discoveries closer to the bedside. Here we describe the essence of a long-term initiative undertaken by The Danish Centre for Translational Breast Cancer Research and currently underway for cancer biomarker discovery using fresh tissue biopsies and bio-fluids. The Centre is a virtual hub that brings together scientists working in various areas of basic cancer research such as cell cycle control, invasion and micro-environmental alterations, apoptosis, cell signaling, and immunology, with clinicians (oncologists, surgeons), pathologists, and epidemiologists, with the aim of understanding the molecular mechanisms underlying breast cancer progression and ultimately of improving patient survival and quality of life. The unifying concept behind our approach is the use of various experimental paradigms for the prospective analysis of clinically relevant samples obtained from the same patient, along with the systematic integration of the biological and clinical data.

Originalsprog	Engelsk
Tidsskrift	Molecular and Cellular Proteomics
Vol/bind	2
Udgave nummer	6
Sider (fra-til)	369-377
Antal sider	9
ISSN	1535-9476
DOI	https://doi.org/10.1074/mcp.R300007-MCP200
Status	Udgivet - 2003

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10.1074/mcp.R300007-MCP200

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Citationsformater

Celis, J. E., Gromov, P., Gromova, I., Moreira, J. M. A., Cabezón, T., Ambartsumian, N., Grigorian, M., Lukanidin, E., Thor Straten, P., Guldberg, P., Bartkova, J., Bartek, J., Lukas, J., Lukas, C., Lykkesfeldt, A., Jäättelä, M., Roepstorff, P., Bolund, L., Ørntoft, T. F., ... Rank, F. E. (2003). Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research. Molecular and Cellular Proteomics, 2(6), 369-377. https://doi.org/10.1074/mcp.R300007-MCP200

Celis, JE, Gromov, P, Gromova, I, Moreira, JMA, Cabezón, T, Ambartsumian, N, Grigorian, M, Lukanidin, E, Thor Straten, P, Guldberg, P, Bartkova, J, Bartek, J, Lukas, J , Lukas, C, Lykkesfeldt, A, Jäättelä, M, Roepstorff, P, Bolund, L, Ørntoft, TF, Brünner, N, Overgaard, J, Sandelin, K, Blichert-Toft, M, Mouridsen, H & Rank, FE 2003, 'Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research', Molecular and Cellular Proteomics, bind 2, nr. 6, s. 369-377. https://doi.org/10.1074/mcp.R300007-MCP200

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abstract = "The application of state-of-the-art proteomics and functional genomics technologies to the study of cancer is rapidly shifting toward the analysis of clinically relevant samples derived from patients, as the ultimate aim of translational research is to bring basic discoveries closer to the bedside. Here we describe the essence of a long-term initiative undertaken by The Danish Centre for Translational Breast Cancer Research and currently underway for cancer biomarker discovery using fresh tissue biopsies and bio-fluids. The Centre is a virtual hub that brings together scientists working in various areas of basic cancer research such as cell cycle control, invasion and micro-environmental alterations, apoptosis, cell signaling, and immunology, with clinicians (oncologists, surgeons), pathologists, and epidemiologists, with the aim of understanding the molecular mechanisms underlying breast cancer progression and ultimately of improving patient survival and quality of life. The unifying concept behind our approach is the use of various experimental paradigms for the prospective analysis of clinically relevant samples obtained from the same patient, along with the systematic integration of the biological and clinical data.",

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AU - Gromov, Pavel

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AU - Moreira, José Manuel Alfonso

AU - Cabezón, Teresa

AU - Ambartsumian, Noona

AU - Grigorian, Mariam

AU - Lukanidin, Eugene

AU - Thor Straten, Per

AU - Guldberg, Per

AU - Bartkova, Jirina

AU - Bartek, Jiri

AU - Lukas, Jiri

AU - Lukas, Claudia

AU - Lykkesfeldt, Anne

AU - Jäättelä, Marja

AU - Roepstorff, Peter

AU - Bolund, Lars

AU - Ørntoft, Torben Falck

AU - Brünner, Nils

AU - Overgaard, Jens

AU - Sandelin, Kerstin

AU - Blichert-Toft, Mogens

AU - Mouridsen, Henning

AU - Rank, Fritz E

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AB - The application of state-of-the-art proteomics and functional genomics technologies to the study of cancer is rapidly shifting toward the analysis of clinically relevant samples derived from patients, as the ultimate aim of translational research is to bring basic discoveries closer to the bedside. Here we describe the essence of a long-term initiative undertaken by The Danish Centre for Translational Breast Cancer Research and currently underway for cancer biomarker discovery using fresh tissue biopsies and bio-fluids. The Centre is a virtual hub that brings together scientists working in various areas of basic cancer research such as cell cycle control, invasion and micro-environmental alterations, apoptosis, cell signaling, and immunology, with clinicians (oncologists, surgeons), pathologists, and epidemiologists, with the aim of understanding the molecular mechanisms underlying breast cancer progression and ultimately of improving patient survival and quality of life. The unifying concept behind our approach is the use of various experimental paradigms for the prospective analysis of clinically relevant samples obtained from the same patient, along with the systematic integration of the biological and clinical data.

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KW - Biomedical Research

KW - Biopsy

KW - Body Fluids

KW - Breast Neoplasms

KW - Denmark

KW - Electrophoresis, Gel, Two-Dimensional

KW - Female

KW - Gene Expression Profiling

KW - Genomics

KW - Humans

KW - Mammary Glands, Human

KW - Pilot Projects

KW - Proteomics

KW - Specimen Handling

KW - Tumor Markers, Biological

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DO - 10.1074/mcp.R300007-MCP200

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SN - 1535-9476

VL - 2

SP - 369

EP - 377

JO - Molecular and Cellular Proteomics

JF - Molecular and Cellular Proteomics

IS - 6

ER -

Integrating proteomic and functional genomic technologies in discovery-driven translational breast cancer research

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