Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation

Feng Wan; Flemming Hofmann Larsen; Heloisa Nunes Bordallo; Camilla Foged; Jukka Rantanen; Mingshi Yang

doi:10.1021/acsami.8b12475

Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation

Feng Wan, Flemming Hofmann Larsen, Heloisa Nunes Bordallo, Camilla Foged, Jukka Rantanen, Mingshi Yang

6 Citations (Scopus)

Abstract

Poly(lactic-co-glycolic acid) (PLGA) microparticles represent a promising formulation approach for providing steady pharmacokinetic/pharmacodynamic profiles of therapeutic drugs for a long period. Understanding and controlling the supramolecular structure of PLGA microparticles at a molecular level is a prerequisite for the rational design of well-controlled, reproducible sustained-release profiles. Herein, we reveal the role of PLGA molecular conformation in particle formation and drug release. The nanoscale network of PLGA microparticles spray-dried using the solvents with distinct polarities was investigated by using NMR and neutron scattering. By employing chemometric method, we further demonstrate the evolution of nanoscale networks in spray-dried PLGA microparticles upon water absorption. Our results indicate that PLGA molecules form more chain entanglements during spray drying when using the solvents with low polarity, where PLGA molecule adopts a more flexible, extended conformation, resulting in the network being more resistant to water absorption in spray-dried PLGA microparticles. This work underlines the role of PLGA molecular conformation in controlling formation and evolution of nanoscale network of spray-dried PLGA microparticles and will have important consequences in achieving customized drug release from the PLGA microparticles.

Original language	English
Journal	A C S Applied Materials and Interfaces
Volume	10
Issue number	43
Pages (from-to)	36686-36692
ISSN	1944-8244
DOIs	https://doi.org/10.1021/acsami.8b12475
Publication status	Published - 31 Oct 2018

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10.1021/acsami.8b12475

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title = "Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation",

abstract = "Poly(lactic-co-glycolic acid) (PLGA) microparticles represent a promising formulation approach for providing steady pharmacokinetic/pharmacodynamic profiles of therapeutic drugs for a long period. Understanding and controlling the supramolecular structure of PLGA microparticles at a molecular level is a prerequisite for the rational design of well-controlled, reproducible sustained-release profiles. Herein, we reveal the role of PLGA molecular conformation in particle formation and drug release. The nanoscale network of PLGA microparticles spray-dried using the solvents with distinct polarities was investigated by using NMR and neutron scattering. By employing chemometric method, we further demonstrate the evolution of nanoscale networks in spray-dried PLGA microparticles upon water absorption. Our results indicate that PLGA molecules form more chain entanglements during spray drying when using the solvents with low polarity, where PLGA molecule adopts a more flexible, extended conformation, resulting in the network being more resistant to water absorption in spray-dried PLGA microparticles. This work underlines the role of PLGA molecular conformation in controlling formation and evolution of nanoscale network of spray-dried PLGA microparticles and will have important consequences in achieving customized drug release from the PLGA microparticles.",

author = "Feng Wan and Larsen, {Flemming Hofmann} and {Nunes Bordallo}, Heloisa and Camilla Foged and Jukka Rantanen and Mingshi Yang",

year = "2018",

month = oct,

day = "31",

doi = "10.1021/acsami.8b12475",

language = "English",

volume = "10",

pages = "36686--36692",

journal = "ACS Applied Materials and Interfaces",

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TY - JOUR

T1 - Insight into Nanoscale Network of Spray-dried Polymeric Particles

T2 - Role of Polymer Molecular Conformation

AU - Wan, Feng

AU - Larsen, Flemming Hofmann

AU - Nunes Bordallo, Heloisa

AU - Foged, Camilla

AU - Rantanen, Jukka

AU - Yang, Mingshi

PY - 2018/10/31

Y1 - 2018/10/31

N2 - Poly(lactic-co-glycolic acid) (PLGA) microparticles represent a promising formulation approach for providing steady pharmacokinetic/pharmacodynamic profiles of therapeutic drugs for a long period. Understanding and controlling the supramolecular structure of PLGA microparticles at a molecular level is a prerequisite for the rational design of well-controlled, reproducible sustained-release profiles. Herein, we reveal the role of PLGA molecular conformation in particle formation and drug release. The nanoscale network of PLGA microparticles spray-dried using the solvents with distinct polarities was investigated by using NMR and neutron scattering. By employing chemometric method, we further demonstrate the evolution of nanoscale networks in spray-dried PLGA microparticles upon water absorption. Our results indicate that PLGA molecules form more chain entanglements during spray drying when using the solvents with low polarity, where PLGA molecule adopts a more flexible, extended conformation, resulting in the network being more resistant to water absorption in spray-dried PLGA microparticles. This work underlines the role of PLGA molecular conformation in controlling formation and evolution of nanoscale network of spray-dried PLGA microparticles and will have important consequences in achieving customized drug release from the PLGA microparticles.

AB - Poly(lactic-co-glycolic acid) (PLGA) microparticles represent a promising formulation approach for providing steady pharmacokinetic/pharmacodynamic profiles of therapeutic drugs for a long period. Understanding and controlling the supramolecular structure of PLGA microparticles at a molecular level is a prerequisite for the rational design of well-controlled, reproducible sustained-release profiles. Herein, we reveal the role of PLGA molecular conformation in particle formation and drug release. The nanoscale network of PLGA microparticles spray-dried using the solvents with distinct polarities was investigated by using NMR and neutron scattering. By employing chemometric method, we further demonstrate the evolution of nanoscale networks in spray-dried PLGA microparticles upon water absorption. Our results indicate that PLGA molecules form more chain entanglements during spray drying when using the solvents with low polarity, where PLGA molecule adopts a more flexible, extended conformation, resulting in the network being more resistant to water absorption in spray-dried PLGA microparticles. This work underlines the role of PLGA molecular conformation in controlling formation and evolution of nanoscale network of spray-dried PLGA microparticles and will have important consequences in achieving customized drug release from the PLGA microparticles.

U2 - 10.1021/acsami.8b12475

DO - 10.1021/acsami.8b12475

M3 - Journal article

C2 - 30211530

SN - 1944-8244

VL - 10

SP - 36686

EP - 36692

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 43

ER -

Insight into Nanoscale Network of Spray-dried Polymeric Particles: Role of Polymer Molecular Conformation

Abstract

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