Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery: A Randomized Controlled Trial

Kirsten C Rasmussen; Michael Højskov; Pär I. Johansson; Irina Kridina; Thomas Klint Kistorp; Lisbeth Salling; Henning B Nielsen; Birgitte Krogsgård Ruhnau; Tom Pedersen; Niels H Secher

doi:10.1097/MD.0000000000002720

Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery: A Randomized Controlled Trial

Kirsten C Rasmussen, Michael Højskov, Pär I. Johansson, Irina Kridina, Thomas Klint Kistorp, Lisbeth Salling, Henning B Nielsen, Birgitte Krogsgård Ruhnau, Tom Pedersen, Niels H Secher

Department of Clinical Medicine

14 Citations (Scopus)

75 Downloads (Pure)

Abstract

For patients exposed to a massive blood loss during surgery, maintained coagulation competence is important. It is less obvious whether coagulation competence influences bleeding during elective surgery where patients are exposed to infusion of a crystalloid or a colloid. This randomized controlled trial evaluates whether administration of 5% human albumin (HA) or lactated Ringer solution (LR) affects coagulation competence and in turn blood loss during cystectomy due to bladder cancer. Forty patients undergoing radical cystectomy were included to receive either 5% HA (n=20) or LR (n=20). Nineteen patients were analyzed in the HA group and 20 patients in the lactated Ringer group.

Original language	English
Article number	e2720
Journal	Medicine (Baltimore)
Volume	95
Issue number	9
Number of pages	6
ISSN	0025-7974
DOIs	https://doi.org/10.1097/MD.0000000000002720
Publication status	Published - 4 Mar 2016

Keywords

Aged
Albumins
Blood Coagulation
Blood Coagulation Tests
Blood Loss, Surgical
Blood Transfusion
Cystectomy
Elective Surgical Procedures
Female
Hematologic Agents
Humans
Isotonic Solutions
Male
Postoperative Hemorrhage
Treatment Outcome
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/MD.0000000000002720Licence: CC BY-ND

Impact of Albumin on Coagulation Competence and Hemorrhage During Major SurgeryLicence: CC BY-ND

Cite this

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title = "Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery: A Randomized Controlled Trial",

abstract = "For patients exposed to a massive blood loss during surgery, maintained coagulation competence is important. It is less obvious whether coagulation competence influences bleeding during elective surgery where patients are exposed to infusion of a crystalloid or a colloid. This randomized controlled trial evaluates whether administration of 5% human albumin (HA) or lactated Ringer solution (LR) affects coagulation competence and in turn blood loss during cystectomy due to bladder cancer. Forty patients undergoing radical cystectomy were included to receive either 5% HA (n=20) or LR (n=20). Nineteen patients were analyzed in the HA group and 20 patients in the lactated Ringer group.",

keywords = "Aged, Albumins, Blood Coagulation, Blood Coagulation Tests, Blood Loss, Surgical, Blood Transfusion, Cystectomy, Elective Surgical Procedures, Female, Hematologic Agents, Humans, Isotonic Solutions, Male, Postoperative Hemorrhage, Treatment Outcome, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",

author = "Rasmussen, {Kirsten C} and Michael H{\o}jskov and Johansson, {P{\"a}r I.} and Irina Kridina and Kistorp, {Thomas Klint} and Lisbeth Salling and Nielsen, {Henning B} and Ruhnau, {Birgitte Krogsg{\aa}rd} and Tom Pedersen and Secher, {Niels H}",

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doi = "10.1097/MD.0000000000002720",

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T1 - Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery

T2 - A Randomized Controlled Trial

AU - Rasmussen, Kirsten C

AU - Højskov, Michael

AU - Johansson, Pär I.

AU - Kridina, Irina

AU - Kistorp, Thomas Klint

AU - Salling, Lisbeth

AU - Nielsen, Henning B

AU - Ruhnau, Birgitte Krogsgård

AU - Pedersen, Tom

AU - Secher, Niels H

PY - 2016/3/4

Y1 - 2016/3/4

N2 - For patients exposed to a massive blood loss during surgery, maintained coagulation competence is important. It is less obvious whether coagulation competence influences bleeding during elective surgery where patients are exposed to infusion of a crystalloid or a colloid. This randomized controlled trial evaluates whether administration of 5% human albumin (HA) or lactated Ringer solution (LR) affects coagulation competence and in turn blood loss during cystectomy due to bladder cancer. Forty patients undergoing radical cystectomy were included to receive either 5% HA (n=20) or LR (n=20). Nineteen patients were analyzed in the HA group and 20 patients in the lactated Ringer group.

AB - For patients exposed to a massive blood loss during surgery, maintained coagulation competence is important. It is less obvious whether coagulation competence influences bleeding during elective surgery where patients are exposed to infusion of a crystalloid or a colloid. This randomized controlled trial evaluates whether administration of 5% human albumin (HA) or lactated Ringer solution (LR) affects coagulation competence and in turn blood loss during cystectomy due to bladder cancer. Forty patients undergoing radical cystectomy were included to receive either 5% HA (n=20) or LR (n=20). Nineteen patients were analyzed in the HA group and 20 patients in the lactated Ringer group.

KW - Aged

KW - Albumins

KW - Blood Coagulation

KW - Blood Coagulation Tests

KW - Blood Loss, Surgical

KW - Blood Transfusion

KW - Cystectomy

KW - Elective Surgical Procedures

KW - Female

KW - Hematologic Agents

KW - Humans

KW - Isotonic Solutions

KW - Male

KW - Postoperative Hemorrhage

KW - Treatment Outcome

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1097/MD.0000000000002720

DO - 10.1097/MD.0000000000002720

M3 - Journal article

C2 - 26945358

SN - 0025-7974

VL - 95

JO - Medicine (Baltimore)

JF - Medicine (Baltimore)

IS - 9

M1 - e2720

ER -

Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery: A Randomized Controlled Trial

Abstract

Keywords

UN SDGs

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