Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery: A Randomized Controlled Trial

Kirsten C Rasmussen; Michael Højskov; Pär I. Johansson; Irina Kridina; Thomas Klint Kistorp; Lisbeth Salling; Henning B Nielsen; Birgitte Krogsgård Ruhnau; Tom Pedersen; Niels H Secher

doi:10.1097/MD.0000000000002720

Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery: A Randomized Controlled Trial

Kirsten C Rasmussen, Michael Højskov, Pär I. Johansson, Irina Kridina, Thomas Klint Kistorp, Lisbeth Salling, Henning B Nielsen, Birgitte Krogsgård Ruhnau, Tom Pedersen, Niels H Secher

Institut for Klinisk Medicin

14 Citationer (Scopus)

75 Downloads (Pure)

Abstract

For patients exposed to a massive blood loss during surgery, maintained coagulation competence is important. It is less obvious whether coagulation competence influences bleeding during elective surgery where patients are exposed to infusion of a crystalloid or a colloid. This randomized controlled trial evaluates whether administration of 5% human albumin (HA) or lactated Ringer solution (LR) affects coagulation competence and in turn blood loss during cystectomy due to bladder cancer. Forty patients undergoing radical cystectomy were included to receive either 5% HA (n=20) or LR (n=20). Nineteen patients were analyzed in the HA group and 20 patients in the lactated Ringer group.

Originalsprog	Engelsk
Artikelnummer	e2720
Tidsskrift	Medicine (Baltimore)
Vol/bind	95
Udgave nummer	9
Antal sider	6
ISSN	0025-7974
DOI	https://doi.org/10.1097/MD.0000000000002720
Status	Udgivet - 4 mar. 2016

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10.1097/MD.0000000000002720Licens: CC BY-ND

Impact of Albumin on Coagulation Competence and Hemorrhage During Major SurgeryLicens: CC BY-ND

Citationsformater

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title = "Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery: A Randomized Controlled Trial",

abstract = "For patients exposed to a massive blood loss during surgery, maintained coagulation competence is important. It is less obvious whether coagulation competence influences bleeding during elective surgery where patients are exposed to infusion of a crystalloid or a colloid. This randomized controlled trial evaluates whether administration of 5% human albumin (HA) or lactated Ringer solution (LR) affects coagulation competence and in turn blood loss during cystectomy due to bladder cancer. Forty patients undergoing radical cystectomy were included to receive either 5% HA (n=20) or LR (n=20). Nineteen patients were analyzed in the HA group and 20 patients in the lactated Ringer group.",

keywords = "Aged, Albumins, Blood Coagulation, Blood Coagulation Tests, Blood Loss, Surgical, Blood Transfusion, Cystectomy, Elective Surgical Procedures, Female, Hematologic Agents, Humans, Isotonic Solutions, Male, Postoperative Hemorrhage, Treatment Outcome, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",

author = "Rasmussen, {Kirsten C} and Michael H{\o}jskov and Johansson, {P{\"a}r I.} and Irina Kridina and Kistorp, {Thomas Klint} and Lisbeth Salling and Nielsen, {Henning B} and Ruhnau, {Birgitte Krogsg{\aa}rd} and Tom Pedersen and Secher, {Niels H}",

year = "2016",

month = mar,

day = "4",

doi = "10.1097/MD.0000000000002720",

language = "English",

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TY - JOUR

T1 - Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery

T2 - A Randomized Controlled Trial

AU - Rasmussen, Kirsten C

AU - Højskov, Michael

AU - Johansson, Pär I.

AU - Kridina, Irina

AU - Kistorp, Thomas Klint

AU - Salling, Lisbeth

AU - Nielsen, Henning B

AU - Ruhnau, Birgitte Krogsgård

AU - Pedersen, Tom

AU - Secher, Niels H

PY - 2016/3/4

Y1 - 2016/3/4

N2 - For patients exposed to a massive blood loss during surgery, maintained coagulation competence is important. It is less obvious whether coagulation competence influences bleeding during elective surgery where patients are exposed to infusion of a crystalloid or a colloid. This randomized controlled trial evaluates whether administration of 5% human albumin (HA) or lactated Ringer solution (LR) affects coagulation competence and in turn blood loss during cystectomy due to bladder cancer. Forty patients undergoing radical cystectomy were included to receive either 5% HA (n=20) or LR (n=20). Nineteen patients were analyzed in the HA group and 20 patients in the lactated Ringer group.

AB - For patients exposed to a massive blood loss during surgery, maintained coagulation competence is important. It is less obvious whether coagulation competence influences bleeding during elective surgery where patients are exposed to infusion of a crystalloid or a colloid. This randomized controlled trial evaluates whether administration of 5% human albumin (HA) or lactated Ringer solution (LR) affects coagulation competence and in turn blood loss during cystectomy due to bladder cancer. Forty patients undergoing radical cystectomy were included to receive either 5% HA (n=20) or LR (n=20). Nineteen patients were analyzed in the HA group and 20 patients in the lactated Ringer group.

KW - Aged

KW - Albumins

KW - Blood Coagulation

KW - Blood Coagulation Tests

KW - Blood Loss, Surgical

KW - Blood Transfusion

KW - Cystectomy

KW - Elective Surgical Procedures

KW - Female

KW - Hematologic Agents

KW - Humans

KW - Isotonic Solutions

KW - Male

KW - Postoperative Hemorrhage

KW - Treatment Outcome

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1097/MD.0000000000002720

DO - 10.1097/MD.0000000000002720

M3 - Journal article

C2 - 26945358

SN - 0025-7974

VL - 95

JO - Medicine (Baltimore)

JF - Medicine (Baltimore)

IS - 9

M1 - e2720

ER -

Impact of Albumin on Coagulation Competence and Hemorrhage During Major Surgery: A Randomized Controlled Trial

Abstract

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