Immunological control of a murine gammaherpesvirus independent of CD8+ T cells

P G Stevenson; R D Cardin; Jan Pravsgaard Christensen; P C Doherty

Immunological control of a murine gammaherpesvirus independent of CD8+ T cells

P G Stevenson, R D Cardin, Jan Pravsgaard Christensen, P C Doherty

Department of Immunology and Microbiology

82 Citations (Scopus)

Abstract

Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.

Original language	English
Journal	Journal of General Virology
Volume	80 ( Pt 2)
Pages (from-to)	477-83
Number of pages	6
ISSN	0022-1317
Publication status	Published - 1999

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title = "Immunological control of a murine gammaherpesvirus independent of CD8+ T cells",

abstract = "Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.",

author = "Stevenson, {P G} and Cardin, {R D} and Christensen, {Jan Pravsgaard} and Doherty, {P C}",

note = "Keywords: Animals; Antibodies, Monoclonal; Antilymphocyte Serum; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Gammaherpesvirinae; Herpesviridae Infections; Lung; Lymphocyte Depletion; Lymphoid Tissue; Mice; Mice, Inbred C57BL",

year = "1999",

language = "English",

volume = "80 ( Pt 2)",

pages = "477--83",

journal = "Journal of General Virology",

issn = "0022-1317",

publisher = "Society for General Microbiology",

}

TY - JOUR

T1 - Immunological control of a murine gammaherpesvirus independent of CD8+ T cells

AU - Stevenson, P G

AU - Cardin, R D

AU - Christensen, Jan Pravsgaard

AU - Doherty, P C

N1 - Keywords: Animals; Antibodies, Monoclonal; Antilymphocyte Serum; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Gammaherpesvirinae; Herpesviridae Infections; Lung; Lymphocyte Depletion; Lymphoid Tissue; Mice; Mice, Inbred C57BL

PY - 1999

Y1 - 1999

N2 - Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.

AB - Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.

M3 - Journal article

C2 - 10073710

SN - 0022-1317

VL - 80 ( Pt 2)

SP - 477

EP - 483

JO - Journal of General Virology

JF - Journal of General Virology

ER -

Immunological control of a murine gammaherpesvirus independent of CD8+ T cells

Abstract

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