@article{77f427c0df6a11ddb5fc000ea68e967b,
title = "Immunological control of a murine gammaherpesvirus independent of CD8+ T cells",
abstract = "Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.",
author = "Stevenson, {P G} and Cardin, {R D} and Christensen, {Jan Pravsgaard} and Doherty, {P C}",
note = "Keywords: Animals; Antibodies, Monoclonal; Antilymphocyte Serum; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Gammaherpesvirinae; Herpesviridae Infections; Lung; Lymphocyte Depletion; Lymphoid Tissue; Mice; Mice, Inbred C57BL",
year = "1999",
language = "English",
volume = "80 ( Pt 2)",
pages = "477--83",
journal = "Journal of General Virology",
issn = "0022-1317",
publisher = "Society for General Microbiology",
}