Abstract
We report on a male who received a bone-marrow allograft from his HLA identical sister for acute myelogenous leukaemia. After transplantation, the patient suffered from refractoriness to the transfusions of HLA-matched platelets and a strong platelet-specific antibody, anti-HPA-2b, of IgG1 subclass was demonstrated in the patient's serum. In the serum of the bone-marrow donor a weak IgG1 anti-HPA-2b was demonstrated. IgG allotyping of the patient and donor showed identical results. We could not determine the origin of the anti-HPA-2b, although we hypothesize that the anti-HPA-2b was produced by immunocompetent donor lymphocytes infused with the suspension of bone-marrow cells.
| Original language | English |
|---|---|
| Journal | British Journal of Haematology |
| Volume | 86 |
| Issue number | 3 |
| Pages (from-to) | 651-3 |
| Number of pages | 2 |
| ISSN | 0007-1048 |
| Publication status | Published - 1994 |