Glucagon-like peptide 1 (GLP-1)

T. D. Mueller; B. Finan; S. R. Bloom; D. D'Alessio; D. J. Drucker; P. R. Flatt; A. Fritsche; F. Gribble; H. J. Grill; J. F. Habener; J. J. Holst; W. Langhans; J. J. Meier; M. A. Nauck; D. Perez-Tilve; A. Pocai; F. Reimann; D. A. Sandoval; T. W. Schwartz; R. J. Seeley; K. Stemmer; M. Tang-Christensen; S. C. Woods; R. D. DiMarchi; M. H. Tschoep

doi:10.1016/j.molmet.2019.09.010

Glucagon-like peptide 1 (GLP-1)

T. D. Mueller, B. Finan, S. R. Bloom, D. D'Alessio, D. J. Drucker, P. R. Flatt, A. Fritsche, F. Gribble, H. J. Grill, J. F. Habener, J. J. Holst, W. Langhans, J. J. Meier, M. A. Nauck, D. Perez-Tilve, A. Pocai, F. Reimann, D. A. Sandoval, T. W. Schwartz, R. J. SeeleyK. Stemmer, M. Tang-Christensen, S. C. Woods, R. D. DiMarchi, M. H. Tschoep

Endocrinology and Metabolism

166 Citations (Scopus)

Abstract

Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of rodent β-cell proliferation. GLP-1 also has cardio- and neuroprotective effects, decreases inflammation and apoptosis, and has implications for learning and memory, reward behavior, and palatability. Biochemically modified for enhanced potency and sustained action, GLP-1 receptor agonists are successfully in clinical use for the treatment of type-2 diabetes, and several GLP-1-based pharmacotherapies are in clinical evaluation for the treatment of obesity. Scope of review: In this review, we provide a detailed overview on the multifaceted nature of GLP-1 and its pharmacology and discuss its therapeutic implications on various diseases. Major conclusions: Since its discovery, GLP-1 has emerged as a pleiotropic hormone with a myriad of metabolic functions that go well beyond its classical identification as an incretin hormone.

Original language	English
Journal	Molecular Metabolism
Volume	30
Pages (from-to)	72-130
ISSN	2212-8778
DOIs	https://doi.org/10.1016/j.molmet.2019.09.010
Publication status	Published - Dec 2019

Keywords

GLP-1
Insulin
Glucagon
Diabetes
Obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Mueller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., Holst, J. J., Langhans, W., Meier, J. J., Nauck, M. A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D. A., Schwartz, T. W., ... Tschoep, M. H. (2019). Glucagon-like peptide 1 (GLP-1). Molecular Metabolism, 30, 72-130. https://doi.org/10.1016/j.molmet.2019.09.010

Mueller, TD, Finan, B, Bloom, SR, D'Alessio, D, Drucker, DJ, Flatt, PR, Fritsche, A, Gribble, F, Grill, HJ, Habener, JF, Holst, JJ, Langhans, W, Meier, JJ, Nauck, MA, Perez-Tilve, D, Pocai, A, Reimann, F, Sandoval, DA, Schwartz, TW, Seeley, RJ, Stemmer, K, Tang-Christensen, M, Woods, SC, DiMarchi, RD & Tschoep, MH 2019, 'Glucagon-like peptide 1 (GLP-1)', Molecular Metabolism, vol. 30, pp. 72-130. https://doi.org/10.1016/j.molmet.2019.09.010

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AU - Mueller, T. D.

AU - Finan, B.

AU - Bloom, S. R.

AU - D'Alessio, D.

AU - Drucker, D. J.

AU - Flatt, P. R.

AU - Fritsche, A.

AU - Gribble, F.

AU - Grill, H. J.

AU - Habener, J. F.

AU - Holst, J. J.

AU - Langhans, W.

AU - Meier, J. J.

AU - Nauck, M. A.

AU - Perez-Tilve, D.

AU - Pocai, A.

AU - Reimann, F.

AU - Sandoval, D. A.

AU - Schwartz, T. W.

AU - Seeley, R. J.

AU - Stemmer, K.

AU - Tang-Christensen, M.

AU - Woods, S. C.

AU - DiMarchi, R. D.

AU - Tschoep, M. H.

PY - 2019/12

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N2 - Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of rodent β-cell proliferation. GLP-1 also has cardio- and neuroprotective effects, decreases inflammation and apoptosis, and has implications for learning and memory, reward behavior, and palatability. Biochemically modified for enhanced potency and sustained action, GLP-1 receptor agonists are successfully in clinical use for the treatment of type-2 diabetes, and several GLP-1-based pharmacotherapies are in clinical evaluation for the treatment of obesity. Scope of review: In this review, we provide a detailed overview on the multifaceted nature of GLP-1 and its pharmacology and discuss its therapeutic implications on various diseases. Major conclusions: Since its discovery, GLP-1 has emerged as a pleiotropic hormone with a myriad of metabolic functions that go well beyond its classical identification as an incretin hormone.

AB - Background: The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose-dependent stimulation of insulin secretion, decrease of gastric emptying, inhibition of food intake, increase of natriuresis and diuresis, and modulation of rodent β-cell proliferation. GLP-1 also has cardio- and neuroprotective effects, decreases inflammation and apoptosis, and has implications for learning and memory, reward behavior, and palatability. Biochemically modified for enhanced potency and sustained action, GLP-1 receptor agonists are successfully in clinical use for the treatment of type-2 diabetes, and several GLP-1-based pharmacotherapies are in clinical evaluation for the treatment of obesity. Scope of review: In this review, we provide a detailed overview on the multifaceted nature of GLP-1 and its pharmacology and discuss its therapeutic implications on various diseases. Major conclusions: Since its discovery, GLP-1 has emerged as a pleiotropic hormone with a myriad of metabolic functions that go well beyond its classical identification as an incretin hormone.

KW - GLP-1

KW - Insulin

KW - Glucagon

KW - Diabetes

KW - Obesity

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DO - 10.1016/j.molmet.2019.09.010

M3 - Review

C2 - 31767182

SN - 2212-8778

VL - 30

SP - 72

EP - 130

JO - Molecular Metabolism

JF - Molecular Metabolism

ER -

Glucagon-like peptide 1 (GLP-1)

Abstract

Keywords

UN SDGs

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