Global daily dynamics of the pineal transcriptome

Diego M Bustos; Michael J Bailey; David Sugden; David A Carter; Martin F Rath; Morten Møller; Steven L Coon; Joan L Weller; David C Klein

doi:10.1007/s00441-010-1094-1

Global daily dynamics of the pineal transcriptome

Diego M Bustos, Michael J Bailey, David Sugden, David A Carter, Martin F Rath, Morten Møller, Steven L Coon, Joan L Weller, David C Klein

14 Citations (Scopus)

Abstract

Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca(2+), cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.

Original language	English
Journal	Cell and Tissue Research
Volume	344
Issue number	1
Pages (from-to)	1-11
Number of pages	11
ISSN	0302-766X
DOIs	https://doi.org/10.1007/s00441-010-1094-1
Publication status	Published - 1 Apr 2011

Keywords

Animals
Circadian Rhythm
Gene Expression Profiling
Gene Expression Regulation
Humans
Pineal Gland

Access to Document

10.1007/s00441-010-1094-1

Cite this

@article{b7677a4d12504e4fb122900265787146,

title = "Global daily dynamics of the pineal transcriptome",

abstract = "Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca(2+), cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.",

keywords = "Animals, Circadian Rhythm, Gene Expression Profiling, Gene Expression Regulation, Humans, Pineal Gland, Neurobiology. gene ekspression",

author = "Bustos, {Diego M} and Bailey, {Michael J} and David Sugden and Carter, {David A} and Rath, {Martin F} and Morten M{\o}ller and Coon, {Steven L} and Weller, {Joan L} and Klein, {David C}",

year = "2011",

month = apr,

day = "1",

doi = "10.1007/s00441-010-1094-1",

language = "English",

volume = "344",

pages = "1--11",

journal = "Cell and Tissue Research",

issn = "0302-766X",

publisher = "Springer",

number = "1",

}

TY - JOUR

T1 - Global daily dynamics of the pineal transcriptome

AU - Bustos, Diego M

AU - Bailey, Michael J

AU - Sugden, David

AU - Carter, David A

AU - Rath, Martin F

AU - Møller, Morten

AU - Coon, Steven L

AU - Weller, Joan L

AU - Klein, David C

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca(2+), cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.

AB - Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca(2+), cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.

KW - Animals

KW - Circadian Rhythm

KW - Gene Expression Profiling

KW - Gene Expression Regulation

KW - Humans

KW - Pineal Gland

KW - Neurobiology. gene ekspression

U2 - 10.1007/s00441-010-1094-1

DO - 10.1007/s00441-010-1094-1

M3 - Journal article

C2 - 21302120

SN - 0302-766X

VL - 344

SP - 1

EP - 11

JO - Cell and Tissue Research

JF - Cell and Tissue Research

IS - 1

ER -

Global daily dynamics of the pineal transcriptome

Abstract

Keywords

Access to Document

Fingerprint

Cite this