TY - JOUR
T1 - Global daily dynamics of the pineal transcriptome
AU - Bustos, Diego M
AU - Bailey, Michael J
AU - Sugden, David
AU - Carter, David A
AU - Rath, Martin F
AU - Møller, Morten
AU - Coon, Steven L
AU - Weller, Joan L
AU - Klein, David C
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca(2+), cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.
AB - Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca(2+), cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.
KW - Animals
KW - Circadian Rhythm
KW - Gene Expression Profiling
KW - Gene Expression Regulation
KW - Humans
KW - Pineal Gland
KW - Neurobiology. gene ekspression
U2 - 10.1007/s00441-010-1094-1
DO - 10.1007/s00441-010-1094-1
M3 - Journal article
C2 - 21302120
SN - 0302-766X
VL - 344
SP - 1
EP - 11
JO - Cell and Tissue Research
JF - Cell and Tissue Research
IS - 1
ER -