Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes

L H Larsen; C S Rose; T Sparsø; J Overgaard; Signe Sørensen Torekov; N Grarup; D P Jensen; Anders Albrechtsen; G Andersen; J Ek; C Glümer; K Borch-Johnsen; T Jørgensen; T Hansen; O Pedersen

doi:10.1038/sj.ijo.0803408

Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes

L H Larsen, C S Rose, T Sparsø, J Overgaard, Signe Sørensen Torekov, N Grarup, D P Jensen, Anders Albrechtsen, G Andersen, J Ek, C Glümer, K Borch-Johnsen, T Jørgensen, T Hansen, O Pedersen

9 Citations (Scopus)

Abstract

The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.

Original language	English
Journal	International Journal of Obesity
Volume	31
Issue number	2
Pages (from-to)	365-70
Number of pages	6
ISSN	0307-0565
DOIs	https://doi.org/10.1038/sj.ijo.0803408
Publication status	Published - 2007

Keywords

Aged
Anthropometry
Blood Glucose
Body Constitution
Chromosomes, Human, Pair 11
DNA Mutational Analysis
Diabetes Mellitus, Type 2
Estrogen Receptor alpha
Female
Genetic Predisposition to Disease
Heat-Shock Proteins
Humans
Insulin
Linkage Disequilibrium
Lipids
Male
Middle Aged
Obesity
Polymorphism, Single Nucleotide
Quantitative Trait, Heritable
Transcription Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.ijo.0803408

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Larsen, L. H., Rose, C. S., Sparsø, T., Overgaard, J., Torekov, S. S., Grarup, N., Jensen, D. P., Albrechtsen, A., Andersen, G., Ek, J., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Hansen, T., & Pedersen, O. (2007). Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes. International Journal of Obesity, 31(2), 365-70. https://doi.org/10.1038/sj.ijo.0803408

Larsen, LH, Rose, CS, Sparsø, T, Overgaard, J, Torekov, SS , Grarup, N, Jensen, DP, Albrechtsen, A, Andersen, G, Ek, J, Glümer, C, Borch-Johnsen, K, Jørgensen, T, Hansen, T & Pedersen, O 2007, 'Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes', International Journal of Obesity, vol. 31, no. 2, pp. 365-70. https://doi.org/10.1038/sj.ijo.0803408

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title = "Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes",

abstract = "The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.",

keywords = "Aged, Anthropometry, Blood Glucose, Body Constitution, Chromosomes, Human, Pair 11, DNA Mutational Analysis, Diabetes Mellitus, Type 2, Estrogen Receptor alpha, Female, Genetic Predisposition to Disease, Heat-Shock Proteins, Humans, Insulin, Linkage Disequilibrium, Lipids, Male, Middle Aged, Obesity, Polymorphism, Single Nucleotide, Quantitative Trait, Heritable, Transcription Factors",

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doi = "10.1038/sj.ijo.0803408",

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AU - Larsen, L H

AU - Rose, C S

AU - Sparsø, T

AU - Overgaard, J

AU - Torekov, Signe Sørensen

AU - Grarup, N

AU - Jensen, D P

AU - Albrechtsen, Anders

AU - Andersen, G

AU - Ek, J

AU - Glümer, C

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Hansen, T

AU - Pedersen, O

PY - 2007

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N2 - The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.

AB - The estrogen-related receptor alpha (ERRalpha or NR3B1) is a transcription factor from the nuclear receptor super-family, group III. The gene encoding ERRalpha (ESRRA) is located on chromosome 11q13, a region showing genetic linkage to body mass index and fat percentage. Through interaction with the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha), ERRalpha regulates key enzymes involved in the beta-oxidation of fatty acids.

KW - Aged

KW - Anthropometry

KW - Blood Glucose

KW - Body Constitution

KW - Chromosomes, Human, Pair 11

KW - DNA Mutational Analysis

KW - Diabetes Mellitus, Type 2

KW - Estrogen Receptor alpha

KW - Female

KW - Genetic Predisposition to Disease

KW - Heat-Shock Proteins

KW - Humans

KW - Insulin

KW - Linkage Disequilibrium

KW - Lipids

KW - Male

KW - Middle Aged

KW - Obesity

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait, Heritable

KW - Transcription Factors

U2 - 10.1038/sj.ijo.0803408

DO - 10.1038/sj.ijo.0803408

M3 - Journal article

C2 - 16755280

SN - 0307-0565

VL - 31

SP - 365

EP - 370

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 2

ER -

Genetic analysis of the estrogen-related receptor alpha and studies of association with obesity and type 2 diabetes

Abstract

Keywords

UN SDGs

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