Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan; Daniel Taliun; Matthias Thurner; Neil R. Robertson; Jason M. Torres; N. William Rayner; Anthony J. Payne; Valgerdur Steinthorsdottir; Robert A. Scott; Niels Grarup; James P. Cook; Ellen M. Schmidt; Matthias Wuttke; Chloe Sarnowski; Reedik Magill; Jana Nano; Christian Gieger; Stella Trompet; Cecile Lecoeur; Michael H. Preuss; Bram Peter Prins; Xiuqing Guo; Lawrence F. Bielak; Jennifer E. Below; Donald W. Bowden; John Campbell Chambers; Young Jin Kim; Maggie C. Y. Ng; Lauren E. Petty; Xueling Sim; Weihua Zhang; Amanda J. Bennett; Jette Bork-Jensen; Chad M. Brummett; Mickael Canouil; Kai-Uwe Ec Kardt; Krista Fischer; Sharon L. R. Kardia; Florian Kronenberg; Kristi Lall; Ching-Ti Liu; Adam E. Locke; Jian'an Luan; Loanna Ntalla; Vibe Nylander; Sebastian Schoenherr; Claudia Schurmann; Loic Yengo; Erwin P. Bottinger; Ivan Brandslund; Cramer Christensen; George Dedoussis; Jose C. Florez; Ian Ford; Oscar H. France; Timothy M. Frayling; Vilmantas Giedraitis; Sophie Hackinger; Andrew T. Hattersley; Christian Herder; M. Arfan Ikram; Martin Ingelsson; Marit E. Jorgensen; Torben Jorgensen; Jennifer Kriebel; Johanna Kuusisto; Symen Ligthart; Cecilia M. Lindgren; Allan Linneberg; Valeriya Lyssenko; Vasiliki Mamakou; Thomas Meitinger; Karen L. Mohlke; Andrew D. Morris; Girish Nadkarni; James S. Pankow; Annette Peters; Naveed Sattar; Alena Stancakova; Konstantin Strauch; Kent D. Taylor; Barbara Thorand; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Jaakko Tuomilehto; Daniel R. Witte; Josee Dupuis; Patricia A. Peyser; Eleftheria Zeggini; Ruth J. F. Loos; Philippe Froguel; Erik Ingelsson; Lars Lind; Leif Groop; Markku Laakso; Francis S. Collins; J. Wouter Jukema; Colin N. A. Palmer; Harald Grallert; Andres Metspalu; Abbas Dehghan; Anna Koettgen; Goncalo R. Abecasis; James B. Meigs; Jerome, I Rotter; Jonathan Marchini; Oluf Pedersen; Torben Hansen; Claudia Langenberg; Nicholas J. Wareham; Kari Stefansson; Anna L. Gloyn; Andrew P. Morris; Michael Boehnke; Mark, I McCarthy

doi:10.1038/s41588-018-0241-6

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, N. William Rayner, Anthony J. Payne, Valgerdur Steinthorsdottir, Robert A. Scott, Niels Grarup, James P. Cook, Ellen M. Schmidt, Matthias Wuttke, Chloe Sarnowski, Reedik Magill, Jana Nano, Christian Gieger, Stella Trompet, Cecile Lecoeur, Michael H. PreussBram Peter Prins, Xiuqing Guo, Lawrence F. Bielak, Jennifer E. Below, Donald W. Bowden, John Campbell Chambers, Young Jin Kim, Maggie C. Y. Ng, Lauren E. Petty, Xueling Sim, Weihua Zhang, Amanda J. Bennett, Jette Bork-Jensen, Chad M. Brummett, Mickael Canouil, Kai-Uwe Ec Kardt, Krista Fischer, Sharon L. R. Kardia, Florian Kronenberg, Kristi Lall, Ching-Ti Liu, Adam E. Locke, Jian'an Luan, Loanna Ntalla, Vibe Nylander, Sebastian Schoenherr, Claudia Schurmann, Loic Yengo, Erwin P. Bottinger, Ivan Brandslund, Cramer Christensen, George Dedoussis, Jose C. Florez, Ian Ford, Oscar H. France, Timothy M. Frayling, Vilmantas Giedraitis, Sophie Hackinger, Andrew T. Hattersley, Christian Herder, M. Arfan Ikram, Martin Ingelsson, Marit E. Jorgensen, Torben Jorgensen, Jennifer Kriebel, Johanna Kuusisto, Symen Ligthart, Cecilia M. Lindgren, Allan Linneberg, Valeriya Lyssenko, Vasiliki Mamakou, Thomas Meitinger, Karen L. Mohlke, Andrew D. Morris, Girish Nadkarni, James S. Pankow, Annette Peters, Naveed Sattar, Alena Stancakova, Konstantin Strauch, Kent D. Taylor, Barbara Thorand, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jaakko Tuomilehto, Daniel R. Witte, Josee Dupuis, Patricia A. Peyser, Eleftheria Zeggini, Ruth J. F. Loos, Philippe Froguel, Erik Ingelsson, Lars Lind, Leif Groop, Markku Laakso, Francis S. Collins, J. Wouter Jukema, Colin N. A. Palmer, Harald Grallert, Andres Metspalu, Abbas Dehghan, Anna Koettgen, Goncalo R. Abecasis, James B. Meigs, Jerome, I Rotter, Jonathan Marchini, Oluf Pedersen, Torben Hansen, Claudia Langenberg, Nicholas J. Wareham, Kari Stefansson, Anna L. Gloyn, Andrew P. Morris, Michael Boehnke, Mark, I McCarthy

350 Citations (Scopus)

Original language	English
Journal	Nature Genetics
Volume	50
Issue number	11
Pages (from-to)	1505-1513
ISSN	1061-4036
DOIs	https://doi.org/10.1038/s41588-018-0241-6
Publication status	Published - 1 Nov 2018

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Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., Payne, A. J., Steinthorsdottir, V., Scott, R. A., Grarup, N., Cook, J. P., Schmidt, E. M., Wuttke, M., Sarnowski, C., Magill, R., Nano, J., Gieger, C., Trompet, S., Lecoeur, C., ... McCarthy, M. I. (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50(11), 1505-1513. https://doi.org/10.1038/s41588-018-0241-6

Mahajan, A, Taliun, D, Thurner, M, Robertson, NR, Torres, JM, Rayner, NW, Payne, AJ, Steinthorsdottir, V, Scott, RA, Grarup, N, Cook, JP, Schmidt, EM, Wuttke, M, Sarnowski, C, Magill, R, Nano, J, Gieger, C, Trompet, S, Lecoeur, C, Preuss, MH, Prins, BP, Guo, X, Bielak, LF, Below, JE, Bowden, DW, Chambers, JC, Kim, YJ, Ng, MCY, Petty, LE, Sim, X, Zhang, W, Bennett, AJ, Bork-Jensen, J, Brummett, CM, Canouil, M, Kardt, K-UE, Fischer, K, Kardia, SLR, Kronenberg, F, Lall, K, Liu, C-T, Locke, AE, Luan, J, Ntalla, L, Nylander, V, Schoenherr, S, Schurmann, C, Yengo, L, Bottinger, EP, Brandslund, I, Christensen, C, Dedoussis, G, Florez, JC, Ford, I, France, OH, Frayling, TM, Giedraitis, V, Hackinger, S, Hattersley, AT, Herder, C, Ikram, MA, Ingelsson, M, Jorgensen, ME, Jorgensen, T, Kriebel, J, Kuusisto, J, Ligthart, S, Lindgren, CM, Linneberg, A, Lyssenko, V, Mamakou, V, Meitinger, T, Mohlke, KL, Morris, AD, Nadkarni, G, Pankow, JS, Peters, A, Sattar, N, Stancakova, A, Strauch, K, Taylor, KD, Thorand, B, Thorleifsson, G, Thorsteinsdottir, U, Tuomilehto, J, Witte, DR, Dupuis, J, Peyser, PA, Zeggini, E, Loos, RJF, Froguel, P, Ingelsson, E, Lind, L, Groop, L, Laakso, M, Collins, FS, Jukema, JW, Palmer, CNA, Grallert, H, Metspalu, A, Dehghan, A, Koettgen, A, Abecasis, GR, Meigs, JB, Rotter, JI, Marchini, J, Pedersen, O , Hansen, T, Langenberg, C, Wareham, NJ, Stefansson, K, Gloyn, AL, Morris, AP, Boehnke, M & McCarthy, MI 2018, 'Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps', Nature Genetics, vol. 50, no. 11, pp. 1505-1513. https://doi.org/10.1038/s41588-018-0241-6

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month = nov,

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doi = "10.1038/s41588-018-0241-6",

language = "English",

volume = "50",

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T1 - Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

AU - Mahajan, Anubha

AU - Taliun, Daniel

AU - Thurner, Matthias

AU - Robertson, Neil R.

AU - Torres, Jason M.

AU - Rayner, N. William

AU - Payne, Anthony J.

AU - Steinthorsdottir, Valgerdur

AU - Scott, Robert A.

AU - Grarup, Niels

AU - Cook, James P.

AU - Schmidt, Ellen M.

AU - Wuttke, Matthias

AU - Sarnowski, Chloe

AU - Magill, Reedik

AU - Nano, Jana

AU - Gieger, Christian

AU - Trompet, Stella

AU - Lecoeur, Cecile

AU - Preuss, Michael H.

AU - Prins, Bram Peter

AU - Guo, Xiuqing

AU - Bielak, Lawrence F.

AU - Below, Jennifer E.

AU - Bowden, Donald W.

AU - Chambers, John Campbell

AU - Kim, Young Jin

AU - Ng, Maggie C. Y.

AU - Petty, Lauren E.

AU - Sim, Xueling

AU - Zhang, Weihua

AU - Bennett, Amanda J.

AU - Bork-Jensen, Jette

AU - Brummett, Chad M.

AU - Canouil, Mickael

AU - Kardt, Kai-Uwe Ec

AU - Fischer, Krista

AU - Kardia, Sharon L. R.

AU - Kronenberg, Florian

AU - Lall, Kristi

AU - Liu, Ching-Ti

AU - Locke, Adam E.

AU - Luan, Jian'an

AU - Ntalla, Loanna

AU - Nylander, Vibe

AU - Schoenherr, Sebastian

AU - Schurmann, Claudia

AU - Yengo, Loic

AU - Bottinger, Erwin P.

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Dedoussis, George

AU - Florez, Jose C.

AU - Ford, Ian

AU - France, Oscar H.

AU - Frayling, Timothy M.

AU - Giedraitis, Vilmantas

AU - Hackinger, Sophie

AU - Hattersley, Andrew T.

AU - Herder, Christian

AU - Ikram, M. Arfan

AU - Ingelsson, Martin

AU - Jorgensen, Marit E.

AU - Jorgensen, Torben

AU - Kriebel, Jennifer

AU - Kuusisto, Johanna

AU - Ligthart, Symen

AU - Lindgren, Cecilia M.

AU - Linneberg, Allan

AU - Lyssenko, Valeriya

AU - Mamakou, Vasiliki

AU - Meitinger, Thomas

AU - Mohlke, Karen L.

AU - Morris, Andrew D.

AU - Nadkarni, Girish

AU - Pankow, James S.

AU - Peters, Annette

AU - Sattar, Naveed

AU - Stancakova, Alena

AU - Strauch, Konstantin

AU - Taylor, Kent D.

AU - Thorand, Barbara

AU - Thorleifsson, Gudmar

AU - Thorsteinsdottir, Unnur

AU - Tuomilehto, Jaakko

AU - Witte, Daniel R.

AU - Dupuis, Josee

AU - Peyser, Patricia A.

AU - Zeggini, Eleftheria

AU - Loos, Ruth J. F.

AU - Froguel, Philippe

AU - Ingelsson, Erik

AU - Lind, Lars

AU - Groop, Leif

AU - Laakso, Markku

AU - Collins, Francis S.

AU - Jukema, J. Wouter

AU - Palmer, Colin N. A.

AU - Grallert, Harald

AU - Metspalu, Andres

AU - Dehghan, Abbas

AU - Koettgen, Anna

AU - Abecasis, Goncalo R.

AU - Meigs, James B.

AU - Rotter, Jerome, I

AU - Marchini, Jonathan

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Langenberg, Claudia

AU - Wareham, Nicholas J.

AU - Stefansson, Kari

AU - Gloyn, Anna L.

AU - Morris, Andrew P.

AU - Boehnke, Michael

AU - McCarthy, Mark, I

PY - 2018/11/1

Y1 - 2018/11/1

U2 - 10.1038/s41588-018-0241-6

DO - 10.1038/s41588-018-0241-6

M3 - Journal article

C2 - 30297969

SN - 1061-4036

VL - 50

SP - 1505

EP - 1513

JO - Nature: New biology

JF - Nature: New biology

IS - 11

ER -

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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