Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan; Daniel Taliun; Matthias Thurner; Neil R. Robertson; Jason M. Torres; N. William Rayner; Anthony J. Payne; Valgerdur Steinthorsdottir; Robert A. Scott; Niels Grarup; James P. Cook; Ellen M. Schmidt; Matthias Wuttke; Chloe Sarnowski; Reedik Magill; Jana Nano; Christian Gieger; Stella Trompet; Cecile Lecoeur; Michael H. Preuss; Bram Peter Prins; Xiuqing Guo; Lawrence F. Bielak; Jennifer E. Below; Donald W. Bowden; John Campbell Chambers; Young Jin Kim; Maggie C. Y. Ng; Lauren E. Petty; Xueling Sim; Weihua Zhang; Amanda J. Bennett; Jette Bork-Jensen; Chad M. Brummett; Mickael Canouil; Kai-Uwe Ec Kardt; Krista Fischer; Sharon L. R. Kardia; Florian Kronenberg; Kristi Lall; Ching-Ti Liu; Adam E. Locke; Jian'an Luan; Loanna Ntalla; Vibe Nylander; Sebastian Schoenherr; Claudia Schurmann; Loic Yengo; Erwin P. Bottinger; Ivan Brandslund; Cramer Christensen; George Dedoussis; Jose C. Florez; Ian Ford; Oscar H. France; Timothy M. Frayling; Vilmantas Giedraitis; Sophie Hackinger; Andrew T. Hattersley; Christian Herder; M. Arfan Ikram; Martin Ingelsson; Marit E. Jorgensen; Torben Jorgensen; Jennifer Kriebel; Johanna Kuusisto; Symen Ligthart; Cecilia M. Lindgren; Allan Linneberg; Valeriya Lyssenko; Vasiliki Mamakou; Thomas Meitinger; Karen L. Mohlke; Andrew D. Morris; Girish Nadkarni; James S. Pankow; Annette Peters; Naveed Sattar; Alena Stancakova; Konstantin Strauch; Kent D. Taylor; Barbara Thorand; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Jaakko Tuomilehto; Daniel R. Witte; Josee Dupuis; Patricia A. Peyser; Eleftheria Zeggini; Ruth J. F. Loos; Philippe Froguel; Erik Ingelsson; Lars Lind; Leif Groop; Markku Laakso; Francis S. Collins; J. Wouter Jukema; Colin N. A. Palmer; Harald Grallert; Andres Metspalu; Abbas Dehghan; Anna Koettgen; Goncalo R. Abecasis; James B. Meigs; Jerome, I Rotter; Jonathan Marchini; Oluf Pedersen; Torben Hansen; Claudia Langenberg; Nicholas J. Wareham; Kari Stefansson; Anna L. Gloyn; Andrew P. Morris; Michael Boehnke; Mark, I McCarthy

doi:10.1038/s41588-018-0241-6

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Anubha Mahajan, Daniel Taliun, Matthias Thurner, Neil R. Robertson, Jason M. Torres, N. William Rayner, Anthony J. Payne, Valgerdur Steinthorsdottir, Robert A. Scott, Niels Grarup, James P. Cook, Ellen M. Schmidt, Matthias Wuttke, Chloe Sarnowski, Reedik Magill, Jana Nano, Christian Gieger, Stella Trompet, Cecile Lecoeur, Michael H. PreussBram Peter Prins, Xiuqing Guo, Lawrence F. Bielak, Jennifer E. Below, Donald W. Bowden, John Campbell Chambers, Young Jin Kim, Maggie C. Y. Ng, Lauren E. Petty, Xueling Sim, Weihua Zhang, Amanda J. Bennett, Jette Bork-Jensen, Chad M. Brummett, Mickael Canouil, Kai-Uwe Ec Kardt, Krista Fischer, Sharon L. R. Kardia, Florian Kronenberg, Kristi Lall, Ching-Ti Liu, Adam E. Locke, Jian'an Luan, Loanna Ntalla, Vibe Nylander, Sebastian Schoenherr, Claudia Schurmann, Loic Yengo, Erwin P. Bottinger, Ivan Brandslund, Cramer Christensen, George Dedoussis, Jose C. Florez, Ian Ford, Oscar H. France, Timothy M. Frayling, Vilmantas Giedraitis, Sophie Hackinger, Andrew T. Hattersley, Christian Herder, M. Arfan Ikram, Martin Ingelsson, Marit E. Jorgensen, Torben Jorgensen, Jennifer Kriebel, Johanna Kuusisto, Symen Ligthart, Cecilia M. Lindgren, Allan Linneberg, Valeriya Lyssenko, Vasiliki Mamakou, Thomas Meitinger, Karen L. Mohlke, Andrew D. Morris, Girish Nadkarni, James S. Pankow, Annette Peters, Naveed Sattar, Alena Stancakova, Konstantin Strauch, Kent D. Taylor, Barbara Thorand, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jaakko Tuomilehto, Daniel R. Witte, Josee Dupuis, Patricia A. Peyser, Eleftheria Zeggini, Ruth J. F. Loos, Philippe Froguel, Erik Ingelsson, Lars Lind, Leif Groop, Markku Laakso, Francis S. Collins, J. Wouter Jukema, Colin N. A. Palmer, Harald Grallert, Andres Metspalu, Abbas Dehghan, Anna Koettgen, Goncalo R. Abecasis, James B. Meigs, Jerome, I Rotter, Jonathan Marchini, Oluf Pedersen, Torben Hansen, Claudia Langenberg, Nicholas J. Wareham, Kari Stefansson, Anna L. Gloyn, Andrew P. Morris, Michael Boehnke, Mark, I McCarthy

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Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	50
Udgave nummer	11
Sider (fra-til)	1505-1513
ISSN	1061-4036
DOI	https://doi.org/10.1038/s41588-018-0241-6
Status	Udgivet - 1 nov. 2018

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10.1038/s41588-018-0241-6

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Mahajan, A., Taliun, D., Thurner, M., Robertson, N. R., Torres, J. M., Rayner, N. W., Payne, A. J., Steinthorsdottir, V., Scott, R. A., Grarup, N., Cook, J. P., Schmidt, E. M., Wuttke, M., Sarnowski, C., Magill, R., Nano, J., Gieger, C., Trompet, S., Lecoeur, C., ... McCarthy, M. I. (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50(11), 1505-1513. https://doi.org/10.1038/s41588-018-0241-6

Mahajan, A, Taliun, D, Thurner, M, Robertson, NR, Torres, JM, Rayner, NW, Payne, AJ, Steinthorsdottir, V, Scott, RA, Grarup, N, Cook, JP, Schmidt, EM, Wuttke, M, Sarnowski, C, Magill, R, Nano, J, Gieger, C, Trompet, S, Lecoeur, C, Preuss, MH, Prins, BP, Guo, X, Bielak, LF, Below, JE, Bowden, DW, Chambers, JC, Kim, YJ, Ng, MCY, Petty, LE, Sim, X, Zhang, W, Bennett, AJ, Bork-Jensen, J, Brummett, CM, Canouil, M, Kardt, K-UE, Fischer, K, Kardia, SLR, Kronenberg, F, Lall, K, Liu, C-T, Locke, AE, Luan, J, Ntalla, L, Nylander, V, Schoenherr, S, Schurmann, C, Yengo, L, Bottinger, EP, Brandslund, I, Christensen, C, Dedoussis, G, Florez, JC, Ford, I, France, OH, Frayling, TM, Giedraitis, V, Hackinger, S, Hattersley, AT, Herder, C, Ikram, MA, Ingelsson, M, Jorgensen, ME, Jorgensen, T, Kriebel, J, Kuusisto, J, Ligthart, S, Lindgren, CM, Linneberg, A, Lyssenko, V, Mamakou, V, Meitinger, T, Mohlke, KL, Morris, AD, Nadkarni, G, Pankow, JS, Peters, A, Sattar, N, Stancakova, A, Strauch, K, Taylor, KD, Thorand, B, Thorleifsson, G, Thorsteinsdottir, U, Tuomilehto, J, Witte, DR, Dupuis, J, Peyser, PA, Zeggini, E, Loos, RJF, Froguel, P, Ingelsson, E, Lind, L, Groop, L, Laakso, M, Collins, FS, Jukema, JW, Palmer, CNA, Grallert, H, Metspalu, A, Dehghan, A, Koettgen, A, Abecasis, GR, Meigs, JB, Rotter, JI, Marchini, J, Pedersen, O , Hansen, T, Langenberg, C, Wareham, NJ, Stefansson, K, Gloyn, AL, Morris, AP, Boehnke, M & McCarthy, MI 2018, 'Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps', Nature Genetics, bind 50, nr. 11, s. 1505-1513. https://doi.org/10.1038/s41588-018-0241-6

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title = "Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps",

author = "Anubha Mahajan and Daniel Taliun and Matthias Thurner and Robertson, {Neil R.} and Torres, {Jason M.} and Rayner, {N. William} and Payne, {Anthony J.} and Valgerdur Steinthorsdottir and Scott, {Robert A.} and Niels Grarup and Cook, {James P.} and Schmidt, {Ellen M.} and Matthias Wuttke and Chloe Sarnowski and Reedik Magill and Jana Nano and Christian Gieger and Stella Trompet and Cecile Lecoeur and Preuss, {Michael H.} and Prins, {Bram Peter} and Xiuqing Guo and Bielak, {Lawrence F.} and Below, {Jennifer E.} and Bowden, {Donald W.} and Chambers, {John Campbell} and Kim, {Young Jin} and Ng, {Maggie C. Y.} and Petty, {Lauren E.} and Xueling Sim and Weihua Zhang and Bennett, {Amanda J.} and Jette Bork-Jensen and Brummett, {Chad M.} and Mickael Canouil and Kardt, {Kai-Uwe Ec} and Krista Fischer and Kardia, {Sharon L. R.} and Florian Kronenberg and Kristi Lall and Ching-Ti Liu and Locke, {Adam E.} and Jian'an Luan and Loanna Ntalla and Vibe Nylander and Sebastian Schoenherr and Claudia Schurmann and Loic Yengo and Bottinger, {Erwin P.} and Ivan Brandslund and Cramer Christensen and George Dedoussis and Florez, {Jose C.} and Ian Ford and France, {Oscar H.} and Frayling, {Timothy M.} and Vilmantas Giedraitis and Sophie Hackinger and Hattersley, {Andrew T.} and Christian Herder and Ikram, {M. Arfan} and Martin Ingelsson and Jorgensen, {Marit E.} and Torben Jorgensen and Jennifer Kriebel and Johanna Kuusisto and Symen Ligthart and Lindgren, {Cecilia M.} and Allan Linneberg and Valeriya Lyssenko and Vasiliki Mamakou and Thomas Meitinger and Mohlke, {Karen L.} and Morris, {Andrew D.} and Girish Nadkarni and Pankow, {James S.} and Annette Peters and Naveed Sattar and Alena Stancakova and Konstantin Strauch and Taylor, {Kent D.} and Barbara Thorand and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Jaakko Tuomilehto and Witte, {Daniel R.} and Josee Dupuis and Peyser, {Patricia A.} and Eleftheria Zeggini and Loos, {Ruth J. F.} and Philippe Froguel and Erik Ingelsson and Lars Lind and Leif Groop and Markku Laakso and Collins, {Francis S.} and Jukema, {J. Wouter} and Palmer, {Colin N. A.} and Harald Grallert and Andres Metspalu and Abbas Dehghan and Anna Koettgen and Abecasis, {Goncalo R.} and Meigs, {James B.} and Rotter, {Jerome, I} and Jonathan Marchini and Oluf Pedersen and Torben Hansen and Claudia Langenberg and Wareham, {Nicholas J.} and Kari Stefansson and Gloyn, {Anna L.} and Morris, {Andrew P.} and Michael Boehnke and McCarthy, {Mark, I}",

year = "2018",

month = nov,

day = "1",

doi = "10.1038/s41588-018-0241-6",

language = "English",

volume = "50",

pages = "1505--1513",

journal = "Nature Genetics",

issn = "1061-4036",

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TY - JOUR

T1 - Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

AU - Mahajan, Anubha

AU - Taliun, Daniel

AU - Thurner, Matthias

AU - Robertson, Neil R.

AU - Torres, Jason M.

AU - Rayner, N. William

AU - Payne, Anthony J.

AU - Steinthorsdottir, Valgerdur

AU - Scott, Robert A.

AU - Grarup, Niels

AU - Cook, James P.

AU - Schmidt, Ellen M.

AU - Wuttke, Matthias

AU - Sarnowski, Chloe

AU - Magill, Reedik

AU - Nano, Jana

AU - Gieger, Christian

AU - Trompet, Stella

AU - Lecoeur, Cecile

AU - Preuss, Michael H.

AU - Prins, Bram Peter

AU - Guo, Xiuqing

AU - Bielak, Lawrence F.

AU - Below, Jennifer E.

AU - Bowden, Donald W.

AU - Chambers, John Campbell

AU - Kim, Young Jin

AU - Ng, Maggie C. Y.

AU - Petty, Lauren E.

AU - Sim, Xueling

AU - Zhang, Weihua

AU - Bennett, Amanda J.

AU - Bork-Jensen, Jette

AU - Brummett, Chad M.

AU - Canouil, Mickael

AU - Kardt, Kai-Uwe Ec

AU - Fischer, Krista

AU - Kardia, Sharon L. R.

AU - Kronenberg, Florian

AU - Lall, Kristi

AU - Liu, Ching-Ti

AU - Locke, Adam E.

AU - Luan, Jian'an

AU - Ntalla, Loanna

AU - Nylander, Vibe

AU - Schoenherr, Sebastian

AU - Schurmann, Claudia

AU - Yengo, Loic

AU - Bottinger, Erwin P.

AU - Brandslund, Ivan

AU - Christensen, Cramer

AU - Dedoussis, George

AU - Florez, Jose C.

AU - Ford, Ian

AU - France, Oscar H.

AU - Frayling, Timothy M.

AU - Giedraitis, Vilmantas

AU - Hackinger, Sophie

AU - Hattersley, Andrew T.

AU - Herder, Christian

AU - Ikram, M. Arfan

AU - Ingelsson, Martin

AU - Jorgensen, Marit E.

AU - Jorgensen, Torben

AU - Kriebel, Jennifer

AU - Kuusisto, Johanna

AU - Ligthart, Symen

AU - Lindgren, Cecilia M.

AU - Linneberg, Allan

AU - Lyssenko, Valeriya

AU - Mamakou, Vasiliki

AU - Meitinger, Thomas

AU - Mohlke, Karen L.

AU - Morris, Andrew D.

AU - Nadkarni, Girish

AU - Pankow, James S.

AU - Peters, Annette

AU - Sattar, Naveed

AU - Stancakova, Alena

AU - Strauch, Konstantin

AU - Taylor, Kent D.

AU - Thorand, Barbara

AU - Thorleifsson, Gudmar

AU - Thorsteinsdottir, Unnur

AU - Tuomilehto, Jaakko

AU - Witte, Daniel R.

AU - Dupuis, Josee

AU - Peyser, Patricia A.

AU - Zeggini, Eleftheria

AU - Loos, Ruth J. F.

AU - Froguel, Philippe

AU - Ingelsson, Erik

AU - Lind, Lars

AU - Groop, Leif

AU - Laakso, Markku

AU - Collins, Francis S.

AU - Jukema, J. Wouter

AU - Palmer, Colin N. A.

AU - Grallert, Harald

AU - Metspalu, Andres

AU - Dehghan, Abbas

AU - Koettgen, Anna

AU - Abecasis, Goncalo R.

AU - Meigs, James B.

AU - Rotter, Jerome, I

AU - Marchini, Jonathan

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Langenberg, Claudia

AU - Wareham, Nicholas J.

AU - Stefansson, Kari

AU - Gloyn, Anna L.

AU - Morris, Andrew P.

AU - Boehnke, Michael

AU - McCarthy, Mark, I

PY - 2018/11/1

Y1 - 2018/11/1

U2 - 10.1038/s41588-018-0241-6

DO - 10.1038/s41588-018-0241-6

M3 - Journal article

C2 - 30297969

SN - 1061-4036

VL - 50

SP - 1505

EP - 1513

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

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