Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits

Anette Marianne Prior Gjesing; Claus Thorn Ekstrøm; Hans Rudolf Lytchoff Eiberg; S.A. Urhammer; Jens Juul Holst; Oluf Pedersen; Teis Hansen

doi:10.1007/s00125-012-2484-6

Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits

Anette Marianne Prior Gjesing, Claus Thorn Ekstrøm, Hans Rudolf Lytchoff Eiberg, S.A. Urhammer, Jens Juul Holst, Oluf Pedersen, Teis Hansen

20 Citations (Scopus)

Abstract

Aims/hypothesis Heritability estimates have shown a varying degree of genetic contribution to traits related to type 2 diabetes. Therefore, the objective of this study was to investigate the familiality of fasting and stimulated measures of plasma glucose, serum insulin, serum C-peptide, plasma glucose-dependent insulinotropic polypeptide (GIP) and plasma glucagon-like peptide-1 (GLP-1) among nondiabetic relatives of Danish type 2 diabetic patients. Methods Sixty-one families comprising 193 non-diabetic offspring, 29 non-diabetic spouses, 72 non-diabetic relatives (parent, sibling, etc.) and two non-related relatives underwent a 4 h 75 g OGTT with measurements of plasma glucose, serum insulin, serum C-peptide, plasma GIP and plasma GLP-1 levels at 18 time points. Insulin secretion rates (ISR) and beta cell responses to glucose, GIP and GLP-1 were calculated. Familiality was estimated based on OGTTderived measures. Results A high level of familiality was observed during the OGTT for plasma levels of GIP and GLP-1, with peak familiality values of 74±16% and 65±15%, respectively (h2±SE). Familiality values were lower for plasma glucose, serum insulin and serum C-peptide during the OGTT (range 8-48%, 14-44% and 15-61%, respectively). ISR resented the highest familiality value at fasting reaching 59±16%. Beta cell responsiveness to glucose GLP-1 and GIP also revealed a strong genetic influence, with peak familiality estimates of 62±13%, 76±15% and 70±14%, respectively. Conclusions/interpretation Our results suggest that circulating levels of GIP and GLP-1 as well as beta cell response to these incretins are highly familial compared with more commonly investigated measures of glucose homeostasis such as fasting and stimulated plasma glucose, serum insulin and serum C-peptide.

Original language	English
Journal	Diabetologia
Volume	55
Issue number	5
Pages (from-to)	1338-1345
Number of pages	8
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-012-2484-6
Publication status	Published - May 2012

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10.1007/s00125-012-2484-6

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Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits. / Gjesing, Anette Marianne Prior ; Ekstrøm, Claus Thorn ; Eiberg, Hans Rudolf Lytchoff et al.

In: Diabetologia, Vol. 55, No. 5, 05.2012, p. 1338-1345.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits",

abstract = "Aims/hypothesis Heritability estimates have shown a varying degree of genetic contribution to traits related to type 2 diabetes. Therefore, the objective of this study was to investigate the familiality of fasting and stimulated measures of plasma glucose, serum insulin, serum C-peptide, plasma glucose-dependent insulinotropic polypeptide (GIP) and plasma glucagon-like peptide-1 (GLP-1) among nondiabetic relatives of Danish type 2 diabetic patients. Methods Sixty-one families comprising 193 non-diabetic offspring, 29 non-diabetic spouses, 72 non-diabetic relatives (parent, sibling, etc.) and two non-related relatives underwent a 4 h 75 g OGTT with measurements of plasma glucose, serum insulin, serum C-peptide, plasma GIP and plasma GLP-1 levels at 18 time points. Insulin secretion rates (ISR) and beta cell responses to glucose, GIP and GLP-1 were calculated. Familiality was estimated based on OGTTderived measures. Results A high level of familiality was observed during the OGTT for plasma levels of GIP and GLP-1, with peak familiality values of 74±16% and 65±15%, respectively (h2±SE). Familiality values were lower for plasma glucose, serum insulin and serum C-peptide during the OGTT (range 8-48%, 14-44% and 15-61%, respectively). ISR resented the highest familiality value at fasting reaching 59±16%. Beta cell responsiveness to glucose GLP-1 and GIP also revealed a strong genetic influence, with peak familiality estimates of 62±13%, 76±15% and 70±14%, respectively. Conclusions/interpretation Our results suggest that circulating levels of GIP and GLP-1 as well as beta cell response to these incretins are highly familial compared with more commonly investigated measures of glucose homeostasis such as fasting and stimulated plasma glucose, serum insulin and serum C-peptide.",

author = "Gjesing, {Anette Marianne Prior} and Ekstr{\o}m, {Claus Thorn} and Eiberg, {Hans Rudolf Lytchoff} and S.A. Urhammer and Holst, {Jens Juul} and Oluf Pedersen and Teis Hansen",

year = "2012",

month = may,

doi = "10.1007/s00125-012-2484-6",

language = "English",

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T1 - Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits

AU - Gjesing, Anette Marianne Prior

AU - Ekstrøm, Claus Thorn

AU - Eiberg, Hans Rudolf Lytchoff

AU - Urhammer, S.A.

AU - Holst, Jens Juul

AU - Pedersen, Oluf

AU - Hansen, Teis

PY - 2012/5

Y1 - 2012/5

N2 - Aims/hypothesis Heritability estimates have shown a varying degree of genetic contribution to traits related to type 2 diabetes. Therefore, the objective of this study was to investigate the familiality of fasting and stimulated measures of plasma glucose, serum insulin, serum C-peptide, plasma glucose-dependent insulinotropic polypeptide (GIP) and plasma glucagon-like peptide-1 (GLP-1) among nondiabetic relatives of Danish type 2 diabetic patients. Methods Sixty-one families comprising 193 non-diabetic offspring, 29 non-diabetic spouses, 72 non-diabetic relatives (parent, sibling, etc.) and two non-related relatives underwent a 4 h 75 g OGTT with measurements of plasma glucose, serum insulin, serum C-peptide, plasma GIP and plasma GLP-1 levels at 18 time points. Insulin secretion rates (ISR) and beta cell responses to glucose, GIP and GLP-1 were calculated. Familiality was estimated based on OGTTderived measures. Results A high level of familiality was observed during the OGTT for plasma levels of GIP and GLP-1, with peak familiality values of 74±16% and 65±15%, respectively (h2±SE). Familiality values were lower for plasma glucose, serum insulin and serum C-peptide during the OGTT (range 8-48%, 14-44% and 15-61%, respectively). ISR resented the highest familiality value at fasting reaching 59±16%. Beta cell responsiveness to glucose GLP-1 and GIP also revealed a strong genetic influence, with peak familiality estimates of 62±13%, 76±15% and 70±14%, respectively. Conclusions/interpretation Our results suggest that circulating levels of GIP and GLP-1 as well as beta cell response to these incretins are highly familial compared with more commonly investigated measures of glucose homeostasis such as fasting and stimulated plasma glucose, serum insulin and serum C-peptide.

AB - Aims/hypothesis Heritability estimates have shown a varying degree of genetic contribution to traits related to type 2 diabetes. Therefore, the objective of this study was to investigate the familiality of fasting and stimulated measures of plasma glucose, serum insulin, serum C-peptide, plasma glucose-dependent insulinotropic polypeptide (GIP) and plasma glucagon-like peptide-1 (GLP-1) among nondiabetic relatives of Danish type 2 diabetic patients. Methods Sixty-one families comprising 193 non-diabetic offspring, 29 non-diabetic spouses, 72 non-diabetic relatives (parent, sibling, etc.) and two non-related relatives underwent a 4 h 75 g OGTT with measurements of plasma glucose, serum insulin, serum C-peptide, plasma GIP and plasma GLP-1 levels at 18 time points. Insulin secretion rates (ISR) and beta cell responses to glucose, GIP and GLP-1 were calculated. Familiality was estimated based on OGTTderived measures. Results A high level of familiality was observed during the OGTT for plasma levels of GIP and GLP-1, with peak familiality values of 74±16% and 65±15%, respectively (h2±SE). Familiality values were lower for plasma glucose, serum insulin and serum C-peptide during the OGTT (range 8-48%, 14-44% and 15-61%, respectively). ISR resented the highest familiality value at fasting reaching 59±16%. Beta cell responsiveness to glucose GLP-1 and GIP also revealed a strong genetic influence, with peak familiality estimates of 62±13%, 76±15% and 70±14%, respectively. Conclusions/interpretation Our results suggest that circulating levels of GIP and GLP-1 as well as beta cell response to these incretins are highly familial compared with more commonly investigated measures of glucose homeostasis such as fasting and stimulated plasma glucose, serum insulin and serum C-peptide.

U2 - 10.1007/s00125-012-2484-6

DO - 10.1007/s00125-012-2484-6

M3 - Journal article

C2 - 22349073

SN - 0012-186X

VL - 55

SP - 1338

EP - 1345

JO - Diabetologia

JF - Diabetologia

IS - 5

ER -

Fasting and oral glucose-stimulated levels of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are highly familial traits

Abstract

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