Estimating the probability of allelic drop-out of STR alleles in forensic genetics

Torben Tvedebrink; Poul Svante Eriksen; Helle Smidt Mogensen; Niels Morling

doi:10.1016/j.fsigen.2009.02.002

Estimating the probability of allelic drop-out of STR alleles in forensic genetics

Torben Tvedebrink, Poul Svante Eriksen, Helle Smidt Mogensen, Niels Morling

87 Citations (Scopus)

Abstract

In crime cases with available DNA evidence, the amount of DNA is often sparse due to the setting of the crime. In such cases, allelic drop-out of one or more true alleles in STR typing is possible. We present a statistical model for estimating the per locus and overall probability of allelic drop-out using the results of all STR loci in the case sample as reference. The methodology of logistic regression is appropriate for this analysis, and we demonstrate how to incorporate this in a forensic genetic framework.

Original language	English
Journal	Forensic Science International: Genetics
Volume	3
Issue number	4
Pages (from-to)	222-6
Number of pages	5
ISSN	1872-4973
DOIs	https://doi.org/10.1016/j.fsigen.2009.02.002
Publication status	Published - 2009

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10.1016/j.fsigen.2009.02.002

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abstract = "In crime cases with available DNA evidence, the amount of DNA is often sparse due to the setting of the crime. In such cases, allelic drop-out of one or more true alleles in STR typing is possible. We present a statistical model for estimating the per locus and overall probability of allelic drop-out using the results of all STR loci in the case sample as reference. The methodology of logistic regression is appropriate for this analysis, and we demonstrate how to incorporate this in a forensic genetic framework.",

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JO - Forensic Science International: Genetics

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Estimating the probability of allelic drop-out of STR alleles in forensic genetics

Abstract

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