Endurance training enhances BDNF release from the human brain

Thomas Seifert; Patrice Brassard; Mads Wissenberg; Peter Kristian Rasmussen; Pernille Nordby; Bente Merete Stallknecht; Helle Adser Hassing; Anne Hviid Jakobsen; Henriette Pilegaard; Henning Morris Bay Nielsen; Niels H. Secher

doi:10.1152/ajpregu.00525.2009

Endurance training enhances BDNF release from the human brain

Thomas Seifert, Patrice Brassard, Mads Wissenberg, Peter Kristian Rasmussen, Pernille Nordby, Bente Merete Stallknecht, Helle Adser Hassing, Anne Hviid Jakobsen, Henriette Pilegaard, Henning Morris Bay Nielsen, Niels H. Secher

261 Citations (Scopus)

Abstract

The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production in the hippocampus and cerebral cortex, we hypothesized that endurance training would enhance the release of BDNF from the human brain as detected from arterial and internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo of endurance training (n = 7) or served as controls (n = 5). Before and after the intervention, blood samples were obtained at rest and during exercise. At baseline, the training group (58 ± 106 ng·100 g ^-1·min^-1, means ± SD) and the control group (12 ± 17 ng·100 g^-1·min^-1) had a similar release of BDNF from the brain at rest. Three months of endurance training enhanced the resting release of BDNF to 206 ± 108 ng·100 g^-1·min^-1 (P < 0.05), with no significant change in the control subjects, but there was no training-induced increase in the release of BDNF during exercise. Additionally, eight mice completed a 5-wk treadmill running training protocol that increased the BDNF mRNA expression in the hippocampus (4.5 ± 1.6 vs. 1.4 ± 1.1 mRNA/ssDNA; P < 0.05), but not in the cerebral cortex (4.0 ± 1.4 vs. 4.6 ± 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health.

Original language	English
Journal	American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Volume	298
Issue number	2
Pages (from-to)	R372-R377
Number of pages	6
ISSN	0363-6119
DOIs	https://doi.org/10.1152/ajpregu.00525.2009
Publication status	Published - Feb 2010

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Seifert, T., Brassard, P., Wissenberg, M., Rasmussen, P. K., Nordby, P., Stallknecht, B. M., Hassing, H. A., Jakobsen, A. H., Pilegaard, H., Nielsen, H. M. B., & Secher, N. H. (2010). Endurance training enhances BDNF release from the human brain. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 298(2), R372-R377. https://doi.org/10.1152/ajpregu.00525.2009

Seifert, T, Brassard, P, Wissenberg, M, Rasmussen, PK, Nordby, P, Stallknecht, BM, Hassing, HA, Jakobsen, AH, Pilegaard, H, Nielsen, HMB & Secher, NH 2010, 'Endurance training enhances BDNF release from the human brain', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 298, no. 2, pp. R372-R377. https://doi.org/10.1152/ajpregu.00525.2009

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title = "Endurance training enhances BDNF release from the human brain",

abstract = "The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production in the hippocampus and cerebral cortex, we hypothesized that endurance training would enhance the release of BDNF from the human brain as detected from arterial and internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo of endurance training (n = 7) or served as controls (n = 5). Before and after the intervention, blood samples were obtained at rest and during exercise. At baseline, the training group (58 ± 106 ng·100 g -1·min-1, means ± SD) and the control group (12 ± 17 ng·100 g-1·min-1) had a similar release of BDNF from the brain at rest. Three months of endurance training enhanced the resting release of BDNF to 206 ± 108 ng·100 g-1·min-1 (P < 0.05), with no significant change in the control subjects, but there was no training-induced increase in the release of BDNF during exercise. Additionally, eight mice completed a 5-wk treadmill running training protocol that increased the BDNF mRNA expression in the hippocampus (4.5 ± 1.6 vs. 1.4 ± 1.1 mRNA/ssDNA; P < 0.05), but not in the cerebral cortex (4.0 ± 1.4 vs. 4.6 ± 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health.",

author = "Thomas Seifert and Patrice Brassard and Mads Wissenberg and Rasmussen, {Peter Kristian} and Pernille Nordby and Stallknecht, {Bente Merete} and Hassing, {Helle Adser} and Jakobsen, {Anne Hviid} and Henriette Pilegaard and Nielsen, {Henning Morris Bay} and Secher, {Niels H.}",

note = "Keywords: Adult; Anaerobic Threshold; Animals; Brain Chemistry; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cerebrovascular Circulation; Hippocampus; Humans; Male; Mice; Middle Cerebral Artery; Physical Conditioning, Animal; Physical Endurance; Physical Fitness; RNA, Messenger; Rest",

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doi = "10.1152/ajpregu.00525.2009",

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T1 - Endurance training enhances BDNF release from the human brain

AU - Seifert, Thomas

AU - Brassard, Patrice

AU - Wissenberg, Mads

AU - Rasmussen, Peter Kristian

AU - Nordby, Pernille

AU - Stallknecht, Bente Merete

AU - Hassing, Helle Adser

AU - Jakobsen, Anne Hviid

AU - Pilegaard, Henriette

AU - Nielsen, Henning Morris Bay

AU - Secher, Niels H.

N1 - Keywords: Adult; Anaerobic Threshold; Animals; Brain Chemistry; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cerebrovascular Circulation; Hippocampus; Humans; Male; Mice; Middle Cerebral Artery; Physical Conditioning, Animal; Physical Endurance; Physical Fitness; RNA, Messenger; Rest

PY - 2010/2

Y1 - 2010/2

N2 - The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production in the hippocampus and cerebral cortex, we hypothesized that endurance training would enhance the release of BDNF from the human brain as detected from arterial and internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo of endurance training (n = 7) or served as controls (n = 5). Before and after the intervention, blood samples were obtained at rest and during exercise. At baseline, the training group (58 ± 106 ng·100 g -1·min-1, means ± SD) and the control group (12 ± 17 ng·100 g-1·min-1) had a similar release of BDNF from the brain at rest. Three months of endurance training enhanced the resting release of BDNF to 206 ± 108 ng·100 g-1·min-1 (P < 0.05), with no significant change in the control subjects, but there was no training-induced increase in the release of BDNF during exercise. Additionally, eight mice completed a 5-wk treadmill running training protocol that increased the BDNF mRNA expression in the hippocampus (4.5 ± 1.6 vs. 1.4 ± 1.1 mRNA/ssDNA; P < 0.05), but not in the cerebral cortex (4.0 ± 1.4 vs. 4.6 ± 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health.

AB - The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production in the hippocampus and cerebral cortex, we hypothesized that endurance training would enhance the release of BDNF from the human brain as detected from arterial and internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo of endurance training (n = 7) or served as controls (n = 5). Before and after the intervention, blood samples were obtained at rest and during exercise. At baseline, the training group (58 ± 106 ng·100 g -1·min-1, means ± SD) and the control group (12 ± 17 ng·100 g-1·min-1) had a similar release of BDNF from the brain at rest. Three months of endurance training enhanced the resting release of BDNF to 206 ± 108 ng·100 g-1·min-1 (P < 0.05), with no significant change in the control subjects, but there was no training-induced increase in the release of BDNF during exercise. Additionally, eight mice completed a 5-wk treadmill running training protocol that increased the BDNF mRNA expression in the hippocampus (4.5 ± 1.6 vs. 1.4 ± 1.1 mRNA/ssDNA; P < 0.05), but not in the cerebral cortex (4.0 ± 1.4 vs. 4.6 ± 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health.

U2 - 10.1152/ajpregu.00525.2009

DO - 10.1152/ajpregu.00525.2009

M3 - Journal article

C2 - 19923361

SN - 0363-6119

VL - 298

SP - R372-R377

JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology

IS - 2

ER -

Endurance training enhances BDNF release from the human brain

Abstract

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