TY - JOUR
T1 - Endurance training enhances BDNF release from the human brain
AU - Seifert, Thomas
AU - Brassard, Patrice
AU - Wissenberg, Mads
AU - Rasmussen, Peter Kristian
AU - Nordby, Pernille
AU - Stallknecht, Bente Merete
AU - Hassing, Helle Adser
AU - Jakobsen, Anne Hviid
AU - Pilegaard, Henriette
AU - Nielsen, Henning Morris Bay
AU - Secher, Niels H.
N1 - Keywords: Adult; Anaerobic Threshold; Animals; Brain Chemistry; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cerebrovascular Circulation; Hippocampus; Humans; Male; Mice; Middle Cerebral Artery; Physical Conditioning, Animal; Physical Endurance; Physical Fitness; RNA, Messenger; Rest
PY - 2010/2
Y1 - 2010/2
N2 - The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production in the hippocampus and cerebral cortex, we hypothesized that endurance training would enhance the release of BDNF from the human brain as detected from arterial and internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo of endurance training (n = 7) or served as controls (n = 5). Before and after the intervention, blood samples were obtained at rest and during exercise. At baseline, the training group (58 ± 106 ng·100 g -1·min-1, means ± SD) and the control group (12 ± 17 ng·100 g-1·min-1) had a similar release of BDNF from the brain at rest. Three months of endurance training enhanced the resting release of BDNF to 206 ± 108 ng·100 g-1·min-1 (P < 0.05), with no significant change in the control subjects, but there was no training-induced increase in the release of BDNF during exercise. Additionally, eight mice completed a 5-wk treadmill running training protocol that increased the BDNF mRNA expression in the hippocampus (4.5 ± 1.6 vs. 1.4 ± 1.1 mRNA/ssDNA; P < 0.05), but not in the cerebral cortex (4.0 ± 1.4 vs. 4.6 ± 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health.
AB - The circulating level of brain-derived neurotrophic factor (BDNF) is reduced in patients with major depression and type-2 diabetes. Because acute exercise increases BDNF production in the hippocampus and cerebral cortex, we hypothesized that endurance training would enhance the release of BDNF from the human brain as detected from arterial and internal jugular venous blood samples. In a randomized controlled study, 12 healthy sedentary males carried out 3 mo of endurance training (n = 7) or served as controls (n = 5). Before and after the intervention, blood samples were obtained at rest and during exercise. At baseline, the training group (58 ± 106 ng·100 g -1·min-1, means ± SD) and the control group (12 ± 17 ng·100 g-1·min-1) had a similar release of BDNF from the brain at rest. Three months of endurance training enhanced the resting release of BDNF to 206 ± 108 ng·100 g-1·min-1 (P < 0.05), with no significant change in the control subjects, but there was no training-induced increase in the release of BDNF during exercise. Additionally, eight mice completed a 5-wk treadmill running training protocol that increased the BDNF mRNA expression in the hippocampus (4.5 ± 1.6 vs. 1.4 ± 1.1 mRNA/ssDNA; P < 0.05), but not in the cerebral cortex (4.0 ± 1.4 vs. 4.6 ± 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health.
U2 - 10.1152/ajpregu.00525.2009
DO - 10.1152/ajpregu.00525.2009
M3 - Journal article
C2 - 19923361
SN - 0363-6119
VL - 298
SP - R372-R377
JO - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
JF - American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
IS - 2
ER -
