Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Eilis Hannon; Diana Schendel; Christine Ladd-Acosta; Jakob Grove; Christine Soholm Hansen; Shan V. Andrews; David Michael Hougaard; Michaeline Bresnahan; Ole Mors; Mads Vilhelm Hollegaard; Marie Bækvad-Hansen; Mady Hornig; Preben Bo Mortensen; Anders D. Børglum; Thomas Werge; Marianne Giørtz Pedersen; Merete Nordentoft; Joseph Buxbaum; M. Daniele Fallin; Jonas Bybjerg-Grauholm; Abraham Reichenberg; Jonathan Mill

doi:10.1186/s13073-018-0527-4

Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Eilis Hannon, Diana Schendel, Christine Ladd-Acosta, Jakob Grove, Christine Soholm Hansen, Shan V. Andrews, David Michael Hougaard, Michaeline Bresnahan, Ole Mors, Mads Vilhelm Hollegaard, Marie Bækvad-Hansen, Mady Hornig, Preben Bo Mortensen, Anders D. Børglum, Thomas Werge, Marianne Giørtz Pedersen, Merete Nordentoft, Joseph Buxbaum, M. Daniele Fallin, Jonas Bybjerg-GrauholmAbraham Reichenberg, Jonathan Mill

Department of Clinical Medicine

38 Citations (Scopus)

53 Downloads (Pure)

Original language	English
Article number	19
Journal	Genome Medicine
Volume	10
Number of pages	13
ISSN	1756-994X
DOIs	https://doi.org/10.1186/s13073-018-0527-4
Publication status	Published - 28 Mar 2018

Keywords

Autism
DNA methylation
Genetics
Neonatal
Genome-wide association study (GWAS)
Epigenome-wide association study (EWAS)
Birth
DNA methylation quantitative trait loci (mQTL)
Polygenic risk score
Prenatal smoking

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10.1186/s13073-018-0527-4Licence: CC BY

Elevated polygenic burden for autism is associated with differential DNA methylation at birthFinal published version, 1.5 MBLicence: CC BY

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Hannon, E., Schendel, D., Ladd-Acosta, C., Grove, J., Hansen, C. S., Andrews, S. V., Hougaard, D. M., Bresnahan, M., Mors, O., Hollegaard, M. V., Bækvad-Hansen, M., Hornig, M., Mortensen, P. B., Børglum, A. D., Werge, T., Pedersen, M. G., Nordentoft, M., Buxbaum, J., Fallin, M. D., ... Mill, J. (2018). Elevated polygenic burden for autism is associated with differential DNA methylation at birth. Genome Medicine, 10, Article 19. https://doi.org/10.1186/s13073-018-0527-4

Hannon, E, Schendel, D, Ladd-Acosta, C, Grove, J, Hansen, CS, Andrews, SV, Hougaard, DM, Bresnahan, M, Mors, O, Hollegaard, MV, Bækvad-Hansen, M, Hornig, M, Mortensen, PB, Børglum, AD, Werge, T, Pedersen, MG, Nordentoft, M, Buxbaum, J, Fallin, MD, Bybjerg-Grauholm, J, Reichenberg, A & Mill, J 2018, 'Elevated polygenic burden for autism is associated with differential DNA methylation at birth', Genome Medicine, vol. 10, 19. https://doi.org/10.1186/s13073-018-0527-4

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title = "Elevated polygenic burden for autism is associated with differential DNA methylation at birth",

keywords = "Autism, DNA methylation, Genetics, Neonatal, Genome-wide association study (GWAS), Epigenome-wide association study (EWAS), Birth, DNA methylation quantitative trait loci (mQTL), Polygenic risk score, Prenatal smoking",

author = "Eilis Hannon and Diana Schendel and Christine Ladd-Acosta and Jakob Grove and Hansen, {Christine Soholm} and Andrews, {Shan V.} and Hougaard, {David Michael} and Michaeline Bresnahan and Ole Mors and Hollegaard, {Mads Vilhelm} and Marie B{\ae}kvad-Hansen and Mady Hornig and Mortensen, {Preben Bo} and B{\o}rglum, {Anders D.} and Thomas Werge and Pedersen, {Marianne Gi{\o}rtz} and Merete Nordentoft and Joseph Buxbaum and Fallin, {M. Daniele} and Jonas Bybjerg-Grauholm and Abraham Reichenberg and Jonathan Mill",

year = "2018",

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day = "28",

doi = "10.1186/s13073-018-0527-4",

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TY - JOUR

T1 - Elevated polygenic burden for autism is associated with differential DNA methylation at birth

AU - Hannon, Eilis

AU - Schendel, Diana

AU - Ladd-Acosta, Christine

AU - Grove, Jakob

AU - Hansen, Christine Soholm

AU - Andrews, Shan V.

AU - Hougaard, David Michael

AU - Bresnahan, Michaeline

AU - Mors, Ole

AU - Hollegaard, Mads Vilhelm

AU - Bækvad-Hansen, Marie

AU - Hornig, Mady

AU - Mortensen, Preben Bo

AU - Børglum, Anders D.

AU - Werge, Thomas

AU - Pedersen, Marianne Giørtz

AU - Nordentoft, Merete

AU - Buxbaum, Joseph

AU - Fallin, M. Daniele

AU - Bybjerg-Grauholm, Jonas

AU - Reichenberg, Abraham

AU - Mill, Jonathan

PY - 2018/3/28

Y1 - 2018/3/28

KW - Autism

KW - DNA methylation

KW - Genetics

KW - Neonatal

KW - Genome-wide association study (GWAS)

KW - Epigenome-wide association study (EWAS)

KW - Birth

KW - DNA methylation quantitative trait loci (mQTL)

KW - Polygenic risk score

KW - Prenatal smoking

U2 - 10.1186/s13073-018-0527-4

DO - 10.1186/s13073-018-0527-4

M3 - Journal article

C2 - 29587883

SN - 1756-994X

VL - 10

JO - Genome Medicine

JF - Genome Medicine

M1 - 19

ER -

Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Keywords

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