Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Eilis Hannon; Diana Schendel; Christine Ladd-Acosta; Jakob Grove; Christine Soholm Hansen; Shan V. Andrews; David Michael Hougaard; Michaeline Bresnahan; Ole Mors; Mads Vilhelm Hollegaard; Marie Bækvad-Hansen; Mady Hornig; Preben Bo Mortensen; Anders D. Børglum; Thomas Werge; Marianne Giørtz Pedersen; Merete Nordentoft; Joseph Buxbaum; M. Daniele Fallin; Jonas Bybjerg-Grauholm; Abraham Reichenberg; Jonathan Mill

doi:10.1186/s13073-018-0527-4

Elevated polygenic burden for autism is associated with differential DNA methylation at birth

Eilis Hannon, Diana Schendel, Christine Ladd-Acosta, Jakob Grove, Christine Soholm Hansen, Shan V. Andrews, David Michael Hougaard, Michaeline Bresnahan, Ole Mors, Mads Vilhelm Hollegaard, Marie Bækvad-Hansen, Mady Hornig, Preben Bo Mortensen, Anders D. Børglum, Thomas Werge, Marianne Giørtz Pedersen, Merete Nordentoft, Joseph Buxbaum, M. Daniele Fallin, Jonas Bybjerg-GrauholmAbraham Reichenberg, Jonathan Mill

Institut for Klinisk Medicin

38 Citationer (Scopus)

53 Downloads (Pure)

Originalsprog	Engelsk
Artikelnummer	19
Tidsskrift	Genome Medicine
Vol/bind	10
Antal sider	13
ISSN	1756-994X
DOI	https://doi.org/10.1186/s13073-018-0527-4
Status	Udgivet - 28 mar. 2018

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10.1186/s13073-018-0527-4Licens: CC BY

Elevated polygenic burden for autism is associated with differential DNA methylation at birthForlagets udgivne version, 1,5 MBLicens: CC BY

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Hannon, E., Schendel, D., Ladd-Acosta, C., Grove, J., Hansen, C. S., Andrews, S. V., Hougaard, D. M., Bresnahan, M., Mors, O., Hollegaard, M. V., Bækvad-Hansen, M., Hornig, M., Mortensen, P. B., Børglum, A. D., Werge, T., Pedersen, M. G., Nordentoft, M., Buxbaum, J., Fallin, M. D., ... Mill, J. (2018). Elevated polygenic burden for autism is associated with differential DNA methylation at birth. Genome Medicine, 10, [19]. https://doi.org/10.1186/s13073-018-0527-4

Hannon, E, Schendel, D, Ladd-Acosta, C, Grove, J, Hansen, CS, Andrews, SV, Hougaard, DM, Bresnahan, M, Mors, O, Hollegaard, MV, Bækvad-Hansen, M, Hornig, M, Mortensen, PB, Børglum, AD, Werge, T, Pedersen, MG, Nordentoft, M, Buxbaum, J, Fallin, MD, Bybjerg-Grauholm, J, Reichenberg, A & Mill, J 2018, 'Elevated polygenic burden for autism is associated with differential DNA methylation at birth', Genome Medicine, bind 10, 19. https://doi.org/10.1186/s13073-018-0527-4

@article{fefbd6f12484460ebb5b28660ac05cf5,

title = "Elevated polygenic burden for autism is associated with differential DNA methylation at birth",

keywords = "Autism, DNA methylation, Genetics, Neonatal, Genome-wide association study (GWAS), Epigenome-wide association study (EWAS), Birth, DNA methylation quantitative trait loci (mQTL), Polygenic risk score, Prenatal smoking",

author = "Eilis Hannon and Diana Schendel and Christine Ladd-Acosta and Jakob Grove and Hansen, {Christine Soholm} and Andrews, {Shan V.} and Hougaard, {David Michael} and Michaeline Bresnahan and Ole Mors and Hollegaard, {Mads Vilhelm} and Marie B{\ae}kvad-Hansen and Mady Hornig and Mortensen, {Preben Bo} and B{\o}rglum, {Anders D.} and Thomas Werge and Pedersen, {Marianne Gi{\o}rtz} and Merete Nordentoft and Joseph Buxbaum and Fallin, {M. Daniele} and Jonas Bybjerg-Grauholm and Abraham Reichenberg and Jonathan Mill",

year = "2018",

month = mar,

day = "28",

doi = "10.1186/s13073-018-0527-4",

language = "English",

volume = "10",

journal = "Genome Medicine",

issn = "1756-994X",

publisher = "BioMed Central Ltd.",

}

TY - JOUR

T1 - Elevated polygenic burden for autism is associated with differential DNA methylation at birth

AU - Hannon, Eilis

AU - Schendel, Diana

AU - Ladd-Acosta, Christine

AU - Grove, Jakob

AU - Hansen, Christine Soholm

AU - Andrews, Shan V.

AU - Hougaard, David Michael

AU - Bresnahan, Michaeline

AU - Mors, Ole

AU - Hollegaard, Mads Vilhelm

AU - Bækvad-Hansen, Marie

AU - Hornig, Mady

AU - Mortensen, Preben Bo

AU - Børglum, Anders D.

AU - Werge, Thomas

AU - Pedersen, Marianne Giørtz

AU - Nordentoft, Merete

AU - Buxbaum, Joseph

AU - Fallin, M. Daniele

AU - Bybjerg-Grauholm, Jonas

AU - Reichenberg, Abraham

AU - Mill, Jonathan

PY - 2018/3/28

Y1 - 2018/3/28

KW - Autism

KW - DNA methylation

KW - Genetics

KW - Neonatal

KW - Genome-wide association study (GWAS)

KW - Epigenome-wide association study (EWAS)

KW - Birth

KW - DNA methylation quantitative trait loci (mQTL)

KW - Polygenic risk score

KW - Prenatal smoking

U2 - 10.1186/s13073-018-0527-4

DO - 10.1186/s13073-018-0527-4

M3 - Journal article

C2 - 29587883

SN - 1756-994X

VL - 10

JO - Genome Medicine

JF - Genome Medicine

M1 - 19

ER -

Elevated polygenic burden for autism is associated with differential DNA methylation at birth

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