Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study

Mikkel Hjordt Holm Larsen; Sara Ekeløf; Dunja Kokotovic; Anne Marie Voigt Schou-Pedersen; Jens Lykkesfeldt; Ismael  Gögenur

doi:10.1213/ANE.0000000000002357

Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study

Mikkel Hjordt Holm Larsen, Sara Ekeløf, Dunja Kokotovic, Anne Marie Voigt Schou-Pedersen, Jens Lykkesfeldt, Ismael Gögenur

Lifepharm

4 Citations (Scopus)

Abstract

It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.

Original language	English
Journal	Anesthesia and Analgesia
Volume	125
Issue number	5
Pages (from-to)	1793–1796
ISSN	0003-2999
DOIs	https://doi.org/10.1213/ANE.0000000000002357
Publication status	Published - 1 Nov 2017

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Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study. / Larsen, Mikkel Hjordt Holm; Ekeløf, Sara; Kokotovic, Dunja et al.
In: Anesthesia and Analgesia, Vol. 125, No. 5, 01.11.2017, p. 1793–1796.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.",

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AU - Kokotovic, Dunja

AU - Schou-Pedersen, Anne Marie Voigt

AU - Lykkesfeldt, Jens

AU - Gögenur, Ismael

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AB - It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.

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Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers: A Randomized Controlled Cross-over Pilot Study

Abstract

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