TY - JOUR
T1 - Effect of High Inspiratory Oxygen Fraction on Endothelial Dysfunction in Healthy Volunteers
T2 - A Randomized Controlled Cross-over Pilot Study
AU - Larsen, Mikkel Hjordt Holm
AU - Ekeløf, Sara
AU - Kokotovic, Dunja
AU - Schou-Pedersen, Anne Marie Voigt
AU - Lykkesfeldt, Jens
AU - Gögenur, Ismael
PY - 2017/11/1
Y1 - 2017/11/1
N2 - It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.
AB - It has been suggested that high inspiratory oxygen concentrations during anesthesia may be associated with higher postoperative mortality due to endothelial dysfunction. A randomized controlled crossover study was conducted with 25 healthy male volunteers. They inhaled an oxygen concentration of 30% and 80%. The endothelial function was assessed using noninvasive digital pulse amplitude tonometry (EndoPAT) supported by endothelial biomarkers. The difference in endothelial function between the 2 treatments was 0.05 (95% confidence interval, −0.36 to 0.27; P = .77). Endothelial biomarkers were unaffected. Inhalation of a high oxygen fraction in healthy volunteers did not result in a significant reduction of endothelial function.
U2 - 10.1213/ANE.0000000000002357
DO - 10.1213/ANE.0000000000002357
M3 - Journal article
C2 - 28922226
SN - 0003-2999
VL - 125
SP - 1793
EP - 1796
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 5
ER -