Critical nodes in signalling pathways: insights into insulin action

TY - JOUR

T1 - Critical nodes in signalling pathways

T2 - insights into insulin action

AU - Taniguchi, Cullen M

AU - Emanuelli, Brice

AU - Kahn, C Ronald

PY - 2006/2

Y1 - 2006/2

N2 - Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

AB - Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

KW - Animals

KW - Humans

KW - Insulin

KW - Phosphatidylinositol 3-Kinases

KW - Proto-Oncogene Proteins c-akt

KW - Receptor, Insulin

KW - Signal Transduction

U2 - 10.1038/nrm1837

DO - 10.1038/nrm1837

M3 - Journal article

C2 - 16493415

SN - 1471-0072

VL - 7

SP - 85

EP - 96

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 2

ER -