Critical nodes in signalling pathways: insights into insulin action

Cullen M Taniguchi; Brice Emanuelli; C Ronald Kahn

doi:10.1038/nrm1837

Critical nodes in signalling pathways: insights into insulin action

Cullen M Taniguchi, Brice Emanuelli, C Ronald Kahn

1859 Citationer (Scopus)

Abstract

Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

Originalsprog	Engelsk
Tidsskrift	Nature Reviews. Molecular Cell Biology
Vol/bind	7
Udgave nummer	2
Sider (fra-til)	85-96
Antal sider	12
ISSN	1471-0072
DOI	https://doi.org/10.1038/nrm1837
Status	Udgivet - feb. 2006

Emneord

Animals
Humans
Insulin
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt
Receptor, Insulin
Signal Transduction

Adgang til dokumentet

10.1038/nrm1837

Citationsformater

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KW - Insulin

KW - Phosphatidylinositol 3-Kinases

KW - Proto-Oncogene Proteins c-akt

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KW - Signal Transduction

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