Covalent attachment of antagonists to the a7 nicotinic acetylcholine receptor: synthesis and reactivity of substituted maleimides

Joseph I Ambrus, Jill I Halliday, Nicholas Kanizaj, Nathan Absalom, Kasper Harpsøe, Thomas Balle, Mary Chebib, Malcolm D McLeod

10 Citations (Scopus)

Abstract

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

Original languageEnglish
JournalChemical Communications
Volume48
Issue number53
Pages (from-to)6699-6701
Number of pages3
ISSN1359-7345
DOIs
Publication statusPublished - 6 Jun 2012

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