Could the mechanisms of bariatric surgery hold the key for novel therapies?: report from a Pennington Scientific Symposium

C S Tam; H-R Berthoud; M Bueter; M V Chakravarthy; A Geliebter; A Hajnal; Jens Juul Holst; L Kaplan; W Pories; H Raybould; R Seeley; A Strader; E Ravussin

doi:10.1111/j.1467-789X.2011.00902.x

Could the mechanisms of bariatric surgery hold the key for novel therapies? report from a Pennington Scientific Symposium

C S Tam, H-R Berthoud, M Bueter, M V Chakravarthy, A Geliebter, A Hajnal, Jens Juul Holst, L Kaplan, W Pories, H Raybould, R Seeley, A Strader, E Ravussin

39 Citations (Scopus)

Abstract

Bariatric surgery is the most effective method for promoting dramatic and durable weight loss in morbidly obese subjects. Furthermore, type 2 diabetes is resolved in over 80% of patients. The mechanisms behind the amelioration in metabolic abnormalities are largely unknown but may be due to changes in energy metabolism, gut peptides and food preference. The goal of this meeting was to review the latest research to better understand the mechanisms behind the 'magic' of bariatric surgery. Replication of these effects in a non-surgical manner remains one of the ultimate challenges for the treatment of obesity and diabetes. Promising data on energy metabolism, gastrointestinal physiology, hedonic response and food intake were reviewed and discussed.

Original language	English
Journal	Obesity Reviews
Volume	12
Issue number	11
Pages (from-to)	984-94
Number of pages	11
ISSN	1467-7881
DOIs	https://doi.org/10.1111/j.1467-789X.2011.00902.x
Publication status	Published - Nov 2011

Keywords

Bariatric Surgery
Energy Metabolism
Ghrelin
Glucagon-Like Peptide 1
Humans
Obesity, Morbid
Peptide YY
Weight Loss

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1467-789X.2011.00902.x

Cite this

Tam, C. S., Berthoud, H-R., Bueter, M., Chakravarthy, M. V., Geliebter, A., Hajnal, A., Holst, J. J., Kaplan, L., Pories, W., Raybould, H., Seeley, R., Strader, A., & Ravussin, E. (2011). Could the mechanisms of bariatric surgery hold the key for novel therapies? report from a Pennington Scientific Symposium. Obesity Reviews, 12(11), 984-94. https://doi.org/10.1111/j.1467-789X.2011.00902.x

Tam, CS, Berthoud, H-R, Bueter, M, Chakravarthy, MV, Geliebter, A, Hajnal, A, Holst, JJ, Kaplan, L, Pories, W, Raybould, H, Seeley, R, Strader, A & Ravussin, E 2011, 'Could the mechanisms of bariatric surgery hold the key for novel therapies? report from a Pennington Scientific Symposium', Obesity Reviews, vol. 12, no. 11, pp. 984-94. https://doi.org/10.1111/j.1467-789X.2011.00902.x

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