Could the mechanisms of bariatric surgery hold the key for novel therapies?: report from a Pennington Scientific Symposium

C S Tam; H-R Berthoud; M Bueter; M V Chakravarthy; A Geliebter; A Hajnal; Jens Juul Holst; L Kaplan; W Pories; H Raybould; R Seeley; A Strader; E Ravussin

doi:10.1111/j.1467-789X.2011.00902.x

Could the mechanisms of bariatric surgery hold the key for novel therapies? report from a Pennington Scientific Symposium

C S Tam, H-R Berthoud, M Bueter, M V Chakravarthy, A Geliebter, A Hajnal, Jens Juul Holst, L Kaplan, W Pories, H Raybould, R Seeley, A Strader, E Ravussin

39 Citationer (Scopus)

Abstract

Bariatric surgery is the most effective method for promoting dramatic and durable weight loss in morbidly obese subjects. Furthermore, type 2 diabetes is resolved in over 80% of patients. The mechanisms behind the amelioration in metabolic abnormalities are largely unknown but may be due to changes in energy metabolism, gut peptides and food preference. The goal of this meeting was to review the latest research to better understand the mechanisms behind the 'magic' of bariatric surgery. Replication of these effects in a non-surgical manner remains one of the ultimate challenges for the treatment of obesity and diabetes. Promising data on energy metabolism, gastrointestinal physiology, hedonic response and food intake were reviewed and discussed.

Originalsprog	Engelsk
Tidsskrift	Obesity Reviews
Vol/bind	12
Udgave nummer	11
Sider (fra-til)	984-94
Antal sider	11
ISSN	1467-7881
DOI	https://doi.org/10.1111/j.1467-789X.2011.00902.x
Status	Udgivet - nov. 2011

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10.1111/j.1467-789X.2011.00902.x

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Tam, C. S., Berthoud, H-R., Bueter, M., Chakravarthy, M. V., Geliebter, A., Hajnal, A., Holst, J. J., Kaplan, L., Pories, W., Raybould, H., Seeley, R., Strader, A., & Ravussin, E. (2011). Could the mechanisms of bariatric surgery hold the key for novel therapies? report from a Pennington Scientific Symposium. Obesity Reviews, 12(11), 984-94. https://doi.org/10.1111/j.1467-789X.2011.00902.x

Tam, CS, Berthoud, H-R, Bueter, M, Chakravarthy, MV, Geliebter, A, Hajnal, A, Holst, JJ, Kaplan, L, Pories, W, Raybould, H, Seeley, R, Strader, A & Ravussin, E 2011, 'Could the mechanisms of bariatric surgery hold the key for novel therapies? report from a Pennington Scientific Symposium', Obesity Reviews, bind 12, nr. 11, s. 984-94. https://doi.org/10.1111/j.1467-789X.2011.00902.x

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title = "Could the mechanisms of bariatric surgery hold the key for novel therapies?: report from a Pennington Scientific Symposium",

abstract = "Bariatric surgery is the most effective method for promoting dramatic and durable weight loss in morbidly obese subjects. Furthermore, type 2 diabetes is resolved in over 80% of patients. The mechanisms behind the amelioration in metabolic abnormalities are largely unknown but may be due to changes in energy metabolism, gut peptides and food preference. The goal of this meeting was to review the latest research to better understand the mechanisms behind the 'magic' of bariatric surgery. Replication of these effects in a non-surgical manner remains one of the ultimate challenges for the treatment of obesity and diabetes. Promising data on energy metabolism, gastrointestinal physiology, hedonic response and food intake were reviewed and discussed.",

keywords = "Bariatric Surgery, Energy Metabolism, Ghrelin, Glucagon-Like Peptide 1, Humans, Obesity, Morbid, Peptide YY, Weight Loss",

author = "Tam, {C S} and H-R Berthoud and M Bueter and Chakravarthy, {M V} and A Geliebter and A Hajnal and Holst, {Jens Juul} and L Kaplan and W Pories and H Raybould and R Seeley and A Strader and E Ravussin",

note = "{\textcopyright} 2011 The Authors. obesity reviews {\textcopyright} 2011 International Association for the Study of Obesity.",

year = "2011",

month = nov,

doi = "10.1111/j.1467-789X.2011.00902.x",

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AU - Chakravarthy, M V

AU - Geliebter, A

AU - Hajnal, A

AU - Holst, Jens Juul

AU - Kaplan, L

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AB - Bariatric surgery is the most effective method for promoting dramatic and durable weight loss in morbidly obese subjects. Furthermore, type 2 diabetes is resolved in over 80% of patients. The mechanisms behind the amelioration in metabolic abnormalities are largely unknown but may be due to changes in energy metabolism, gut peptides and food preference. The goal of this meeting was to review the latest research to better understand the mechanisms behind the 'magic' of bariatric surgery. Replication of these effects in a non-surgical manner remains one of the ultimate challenges for the treatment of obesity and diabetes. Promising data on energy metabolism, gastrointestinal physiology, hedonic response and food intake were reviewed and discussed.

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KW - Glucagon-Like Peptide 1

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KW - Obesity, Morbid

KW - Peptide YY

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Could the mechanisms of bariatric surgery hold the key for novel therapies? report from a Pennington Scientific Symposium

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