Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline

Jesper Larsen; Julie Clasen; Julie Elvekjær Hansen; Wilhelm Paulander; Andreas Petersen; Anders Rhod Larsen; Dorte Frees

doi:10.1128/AAC.00426-16

Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline

Jesper Larsen, Julie Clasen, Julie Elvekjær Hansen, Wilhelm Paulander, Andreas Petersen, Anders Rhod Larsen, Dorte Frees

Food Safety and Zoonoses

28 Citations (Scopus)

Abstract

The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	7
Pages (from-to)	4401-4403
ISSN	0066-4804
DOIs	https://doi.org/10.1128/AAC.00426-16
Publication status	Published - Jul 2016

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Larsen, J., Clasen, J., Hansen, J. E., Paulander, W., Petersen, A., Larsen, A. R., & Frees, D. (2016). Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline. Antimicrobial Agents and Chemotherapy, 60(7), 4401-4403. https://doi.org/10.1128/AAC.00426-16

Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline. / Larsen, Jesper; Clasen, Julie; Hansen, Julie Elvekjær et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 60, No. 7, 07.2016, p. 4401-4403.

Research output: Contribution to journal › Journal article › Research › peer-review

Larsen, J, Clasen, J, Hansen, JE, Paulander, W, Petersen, A, Larsen, AR & Frees, D 2016, 'Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline', Antimicrobial Agents and Chemotherapy, vol. 60, no. 7, pp. 4401-4403. https://doi.org/10.1128/AAC.00426-16

Larsen J, Clasen J, Hansen JE, Paulander W, Petersen A, Larsen AR et al. Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline. Antimicrobial Agents and Chemotherapy. 2016 Jul;60(7):4401-4403. doi: 10.1128/AAC.00426-16

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abstract = "The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398.",

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