Research output per year
Research output per year
Personal profile
Short presentation
Staphylococcus aureus is the leading cause of bacterial infections in developed countries and Methicillin-Resistant S. aureus (MRSA) is one of the most significant antibiotic resistant bacteria world-wide. For this reason, my research is dedicated to unravel the molecular mechanisms underlying the ability of Staphylococcus aureus to cause disease and to develop antibiotic resistance. Focus has been on the highly conserved ClpP proteases and Clp chaperones that we have shown to be absolutely essential for the virulence of Staphylococcus aureus. We are currently investigating how the Clp proteases and chaperones central activities such as:
- Virulence gene regulation
- Antibiotic resistance
- Cell division
The long-term objective of my research is to provide the scientific basis for the development of drugs interfering with these mechanisms.
CV
Academic Degrees
cand. scient (1994) University of Copenhangen; Ph. D. (2000) KVL, Department of Food Science
Employments
2000-2003 Assistant professor at the Department of Veterinary Microbiology (KVL).
2003-present Associate professor at the Department of Veterinary Pathobiology KVL (from January the 1 st 2007 KU)
Keywords
- Faculty of Health and Medical Sciences
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Research output
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Antibiotic Resistance and the MRSA Problem
Vestergaard, M., Frees, D. & Ingmer, H., 2019, In: Microbiology Spectrum. 7, 2, 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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SosA inhibits cell division in Staphylococcus aureus in response to DNA damage
Bojer, M. S., Wacnik, K., Kjelgaard, P., Gallay, C., Bottomley, A. L., Cohn, M. T., Lindahl, G., Frees, D., Veening, J. W., Foster, S. J. & Ingmer, H., 1 Oct 2019, In: Molecular Microbiology. 112, 4, p. 1116-1130Research output: Contribution to journal › Journal article › Research › peer-review
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Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision
Jensen, C., Fosberg, M. J., Thalsø-Madsen, I., Bæk, K. T. & Frees, D., 2019, In: Scientific Reports. 9, 11 p., 16456.Research output: Contribution to journal › Journal article › Research › peer-review
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The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis
Jensen, C., Bæk, K. T., Gallay, C., Thalsø-Madsen, I., Xu, L., Jousselin, A., Ruiz Torrubia, F., Paulander, W., Pereira, A. R., Veening, J. W., Pinho, M. G. & Frees, D., 2019, In: PLOS Pathogens. 15, 9, 27 p., e1008044.Research output: Contribution to journal › Journal article › Research › peer-review
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Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease
Baldry, M., Nakamura, Y., Nakagawa, S., Frees, D., Matsue, H., Nunez, G. & Ingmer, H., 14 Aug 2018, In: Journal of Infectious Diseases. 218, 6, p. 1009-1013Research output: Contribution to journal › Journal article › Research › peer-review
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A porcine subcutaneous Staphylococcus aureus abscess model - a pilot study
Nielsen, O. L., Larsen, M. N., Frees, D., Pedersen, M. M., Skov, S. & Olsen, L. H., 2017.Research output: Contribution to conference › Conference abstract for conference › Communication
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The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus
Stahlhut, S. G., Alqarzaee, A. A., Jensen, C., Fisker, N. S., Pereira, A. R., Pinho, M. G., Thomas, V. C. & Frees, D., 1 Dec 2017, In: Scientific Reports. 7, 14 p., 11739.Research output: Contribution to journal › Journal article › Research › peer-review
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Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri
Korbut, R., Mehrdana, F., Kania, P. W., Larsen, M. H., Frees, D., Dalsgaard, I. & Jørgensen, L. V. G., 12 Jul 2016, In: P L o S One. 11, 7, e0158968.Research output: Contribution to journal › Journal article › Research › peer-review
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The ClpP proteases control processes of vital importance for the pathogenesis of Staphylococcus aureus
Frees, D. (Lecturer)
3 Oct 2007Activity: Talk or presentation types › Lecture and oral contribution
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Regulated proteolysis controls vital processes in Staphylococcus aureus
Frees, D. (Lecturer)
5 Sept 2007Activity: Talk or presentation types › Lecture and oral contribution
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Synthesis and activity of the alternative sigma factor, SigB is serely reduced in Staphylococcus aureus cells lacking the ClpP protease
Frees, D. (Lecturer)
23 May 2007Activity: Talk or presentation types › Lecture and oral contribution
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A possible role of ClpP proteases and chaperones in regulating activity of SigmaB
Frees, D. (Lecturer)
23 Jan 2007Activity: Talk or presentation types › Lecture and oral contribution
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FEMS Immunology & Medical Microbiology (Journal)
Frees, D. (Editor)
1 Jan 2007Activity: Publication peer-review and editorial work types › Peer review of manuscripts › Research
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Microbiology (Journal)
Frees, D. (Editor)
1 Jan 2007Activity: Publication peer-review and editorial work types › Peer review of manuscripts › Research
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FEMS Microbiology Letters (Journal)
Frees, D. (Editor)
1 Jan 2007Activity: Publication peer-review and editorial work types › Peer review of manuscripts › Research
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Journal of Applied Microbiology (Journal)
Frees, D. (Editor)
1 Jan 2007Activity: Publication peer-review and editorial work types › Peer review of manuscripts › Research