Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline

Jesper Larsen; Julie Clasen; Julie Elvekjær Hansen; Wilhelm Paulander; Andreas Petersen; Anders Rhod Larsen; Dorte Frees

doi:10.1128/AAC.00426-16

Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline

Jesper Larsen, Julie Clasen, Julie Elvekjær Hansen, Wilhelm Paulander, Andreas Petersen, Anders Rhod Larsen, Dorte Frees

Sektion, Food Safety and Zoonoses

28 Citationer (Scopus)

Abstract

The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398.

Originalsprog	Engelsk
Tidsskrift	Antimicrobial Agents and Chemotherapy
Vol/bind	60
Udgave nummer	7
Sider (fra-til)	4401-4403
ISSN	0066-4804
DOI	https://doi.org/10.1128/AAC.00426-16
Status	Udgivet - jul. 2016

Adgang til dokumentet

10.1128/AAC.00426-16

Fingeraftryk

Dyk ned i forskningsemnerne om 'Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline'. Sammen danner de et unikt fingeraftryk.

Citationsformater

Larsen, J., Clasen, J., Hansen, J. E., Paulander, W., Petersen, A., Larsen, A. R., & Frees, D. (2016). Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline. Antimicrobial Agents and Chemotherapy, 60(7), 4401-4403. https://doi.org/10.1128/AAC.00426-16

Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline. / Larsen, Jesper; Clasen, Julie; Hansen, Julie Elvekjær et al.
I: Antimicrobial Agents and Chemotherapy, Bind 60, Nr. 7, 07.2016, s. 4401-4403.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Larsen, J, Clasen, J, Hansen, JE, Paulander, W, Petersen, A, Larsen, AR & Frees, D 2016, 'Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline', Antimicrobial Agents and Chemotherapy, bind 60, nr. 7, s. 4401-4403. https://doi.org/10.1128/AAC.00426-16

Larsen J, Clasen J, Hansen JE, Paulander W, Petersen A, Larsen AR et al. Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline. Antimicrobial Agents and Chemotherapy. 2016 jul.;60(7):4401-4403. doi: 10.1128/AAC.00426-16

@article{47379723eb904c779307dc1dccb43fee,

title = "Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline",

abstract = "The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398.",

author = "Jesper Larsen and Julie Clasen and Hansen, {Julie Elvekj{\ae}r} and Wilhelm Paulander and Andreas Petersen and Larsen, {Anders Rhod} and Dorte Frees",

year = "2016",

month = jul,

doi = "10.1128/AAC.00426-16",

language = "English",

volume = "60",

pages = "4401--4403",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "7",

}

TY - JOUR

T1 - Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline

AU - Larsen, Jesper

AU - Clasen, Julie

AU - Hansen, Julie Elvekjær

AU - Paulander, Wilhelm

AU - Petersen, Andreas

AU - Larsen, Anders Rhod

AU - Frees, Dorte

PY - 2016/7

Y1 - 2016/7

N2 - The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398.

AB - The tetracycline resistance gene tet(K) was shown to be integrated within the predominant staphylococcal cassette chromosome mec (SCCmec) element of Danish livestock-associated methicillin-resistant Staphylococcus aureus CC398 (LA-MRSA CC398). These LA-MRSA CC398 isolates already possessed tet(M), but the acquisition of tet(K) significantly improved their fitness at sublethal concentrations of tetracycline. Because tet(K) is genetically linked to SCCmec, the use of tetracycline in food animals may have contributed to the successful spread of LA-MRSA CC398.

U2 - 10.1128/AAC.00426-16

DO - 10.1128/AAC.00426-16

M3 - Journal article

C2 - 27161637

SN - 0066-4804

VL - 60

SP - 4401

EP - 4403

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 7

ER -