Convenient synthesis of Ne-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker

Jeanette Marker Andersen; Thomas Hjelmgaard; Lars Ove Dragsted; John Nielsen

doi:10.1055/s-0031-1290348

Convenient synthesis of N^e-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker

Jeanette Marker Andersen, Thomas Hjelmgaard, Lars Ove Dragsted, John Nielsen

3 Citations (Scopus)

Abstract

Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N ^-(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate.

Original language	English
Journal	SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
Volume	23
Issue number	4
Pages (from-to)	531-534
Number of pages	4
ISSN	0936-5214
DOIs	https://doi.org/10.1055/s-0031-1290348
Publication status	Published - 2012

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abstract = "Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N -(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate.",

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AU - Dragsted, Lars Ove

AU - Nielsen, John

PY - 2012

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N2 - Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N -(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate.

AB - Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N -(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate.

U2 - 10.1055/s-0031-1290348

DO - 10.1055/s-0031-1290348

M3 - Letter

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SP - 531

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JO - Synlett

JF - Synlett

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ER -

Convenient synthesis of Ne-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker

Abstract

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Convenient synthesis of N^e-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker