Convenient synthesis of Ne-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker

Jeanette Marker Andersen; Thomas Hjelmgaard; Lars Ove Dragsted; John Nielsen

doi:10.1055/s-0031-1290348

Convenient synthesis of N^e-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker

Jeanette Marker Andersen, Thomas Hjelmgaard, Lars Ove Dragsted, John Nielsen

3 Citationer (Scopus)

Abstract

Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N ^-(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate.

Originalsprog	Engelsk
Tidsskrift	SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
Vol/bind	23
Udgave nummer	4
Sider (fra-til)	531-534
Antal sider	4
ISSN	0936-5214
DOI	https://doi.org/10.1055/s-0031-1290348
Status	Udgivet - 2012

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10.1055/s-0031-1290348

Citationsformater

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title = "Convenient synthesis of Ne-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker",

abstract = "Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N -(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate.",

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T1 - Convenient synthesis of Ne-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker

AU - Andersen, Jeanette Marker

AU - Hjelmgaard, Thomas

AU - Dragsted, Lars Ove

AU - Nielsen, John

PY - 2012

Y1 - 2012

N2 - Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N -(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate.

AB - Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N -(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate.

U2 - 10.1055/s-0031-1290348

DO - 10.1055/s-0031-1290348

M3 - Letter

SN - 0936-5214

VL - 23

SP - 531

EP - 534

JO - Synlett

JF - Synlett

IS - 4

ER -

Convenient synthesis of Ne-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker

Abstract

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Citationsformater

Convenient synthesis of N^e-(Carboxymethyl)lysine, a key advanced glycation endproduct biomarker