Combinatorial chemistry of piperidine based carbohydrate mimics

TY - JOUR

T1 - Combinatorial chemistry of piperidine based carbohydrate mimics

AU - Byrgesen, Elisabeth

AU - Nielsen, John

AU - Willert, Marianne

AU - Bols, Mikael

PY - 1997/8/1

Y1 - 1997/8/1

N2 - Piperidine carboxylic acids and 4-hydroxypiperidine-3-carboxylic acid, the latter obtained from bakers yeast reduction of the corresponding piperidone, were coupled in solid-phase synthesis to form simplified oligosaccharide analogues. A split-and-mix synthesis approach was used to create small combinatorial libraries which were characterised by LC-MS and screened as inhibitors of glycosidases.

AB - Piperidine carboxylic acids and 4-hydroxypiperidine-3-carboxylic acid, the latter obtained from bakers yeast reduction of the corresponding piperidone, were coupled in solid-phase synthesis to form simplified oligosaccharide analogues. A split-and-mix synthesis approach was used to create small combinatorial libraries which were characterised by LC-MS and screened as inhibitors of glycosidases.

U2 - 10.1016/S0040-4039(97)01249-5

DO - 10.1016/S0040-4039(97)01249-5

M3 - Journal article

AN - SCOPUS:0030817956

SN - 0040-4039

VL - 38

SP - 5697

EP - 5700

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 32

ER -