Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

Lars Bo Nielsen; K.B. Ploug; P. Swift; Anne Cathrine Ørskov; I. Jansen-Olesen; F. Chiarelli; J.J. Holst; Poul Philip Hougaard; S. Porksen; R. Holl; C. de Beaufort; S. Gammeltoft; P. Rorsman; Henrik B. Mortensen; L. Hansen; Lotte B Nielsen; Kenneth B Ploug; Peter Swift; Cathrine Ørskov; Inger Jansen-Olesen; Francesco Chiarelli; Jens Juul Holst; Philip Hougaard; Sven Pörksen; Reinhard Holl; Carine de Beaufort; Steen Gammeltoft; Patrik Rorsman; Henrik B Mortensen; Lars Hansen; Hvidøre Study Group

doi:http://dx.doi.org/10.1530/EJE-06-0756

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

Lars Bo Nielsen, K.B. Ploug, P. Swift, Anne Cathrine Ørskov, I. Jansen-Olesen, F. Chiarelli, J.J. Holst, Poul Philip Hougaard, S. Porksen, R. Holl, C. de Beaufort, S. Gammeltoft, P. Rorsman, Henrik B. Mortensen, L. Hansen, Lotte B Nielsen, Kenneth B Ploug, Peter Swift, Cathrine Ørskov, Inger Jansen-OlesenFrancesco Chiarelli, Jens Juul Holst, Philip Hougaard, Sven Pörksen, Reinhard Holl, Carine de Beaufort, Steen Gammeltoft, Patrik Rorsman, Henrik B Mortensen, Lars Hansen, Hvidøre Study Group

56 Citations (Scopus)

Abstract

The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.

Original language	English
Journal	European Journal of Endocrinology
Volume	156
Issue number	6
Pages (from-to)	663-71
Number of pages	9
ISSN	0804-4643
DOIs	https://doi.org/10.1530/EJE-06-0756
Publication status	Published - 2007

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Nielsen, L. B., Ploug, K. B., Swift, P., Ørskov, A. C., Jansen-Olesen, I., Chiarelli, F., Holst, J. J., Hougaard, P. P., Porksen, S., Holl, R., Beaufort, C. D., Gammeltoft, S., Rorsman, P., Mortensen, H. B., Hansen, L., Nielsen, L. B., Ploug, K. B., Swift, P., Ørskov, C., ... Hvidøre Study Group (2007). Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. European Journal of Endocrinology, 156(6), 663-71. https://doi.org/10.1530/EJE-06-0756

Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. / Nielsen, Lars Bo; Ploug, K.B.; Swift, P. et al.

In: European Journal of Endocrinology, Vol. 156, No. 6, 2007, p. 663-71.

Research output: Contribution to journal › Journal article › Research › peer-review

Nielsen, LB, Ploug, KB, Swift, P, Ørskov, AC, Jansen-Olesen, I, Chiarelli, F, Holst, JJ, Hougaard, PP, Porksen, S, Holl, R, Beaufort, CD, Gammeltoft, S, Rorsman, P, Mortensen, HB, Hansen, L, Nielsen, LB, Ploug, KB, Swift, P, Ørskov, C, Jansen-Olesen, I, Chiarelli, F, Holst, JJ, Hougaard, P, Pörksen, S, Holl, R, de Beaufort, C, Gammeltoft, S, Rorsman, P, Mortensen, HB, Hansen, L & Hvidøre Study Group 2007, 'Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes', European Journal of Endocrinology, vol. 156, no. 6, pp. 663-71. https://doi.org/10.1530/EJE-06-0756

Nielsen LB, Ploug KB, Swift P, Ørskov AC, Jansen-Olesen I, Chiarelli F et al. Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes. European Journal of Endocrinology. 2007;156(6):663-71. doi: http://dx.doi.org/10.1530/EJE-06-0756

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title = "Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes",

abstract = "The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.",

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T1 - Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

AU - Nielsen, Lars Bo

AU - Ploug, K.B.

AU - Swift, P.

AU - Ørskov, Anne Cathrine

AU - Jansen-Olesen, I.

AU - Chiarelli, F.

AU - Holst, J.J.

AU - Hougaard, Poul Philip

AU - Porksen, S.

AU - Holl, R.

AU - Beaufort, C. de

AU - Gammeltoft, S.

AU - Rorsman, P.

AU - Mortensen, Henrik B.

AU - Hansen, L.

AU - Nielsen, Lotte B

AU - Ploug, Kenneth B

AU - Swift, Peter

AU - Ørskov, Cathrine

AU - Jansen-Olesen, Inger

AU - Chiarelli, Francesco

AU - Holst, Jens Juul

AU - Hougaard, Philip

AU - Pörksen, Sven

AU - Holl, Reinhard

AU - de Beaufort, Carine

AU - Gammeltoft, Steen

AU - Rorsman, Patrik

AU - Mortensen, Henrik B

AU - Hansen, Lars

AU - Hvidøre Study Group

PY - 2007

Y1 - 2007

N2 - The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.

AB - The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.

U2 - http://dx.doi.org/10.1530/EJE-06-0756

DO - http://dx.doi.org/10.1530/EJE-06-0756

M3 - Journal article

SN - 0804-4643

VL - 156

SP - 663

EP - 671

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 6

ER -