Circadian changes in long noncoding RNAs in the pineal gland

Steven L Coon; Peter J Munson; Praveen F Cherukuri; David Sugden; Martin Fredensborg Rath; Morten Møller; Samuel J H Clokie; Cong Fu; Mary E Olanich; Zoila Rangel; Thomas Werner; NISC Comparative Sequencing Program; James C Mullikin; David C Klein

doi:10.1073/pnas.1207748109

Circadian changes in long noncoding RNAs in the pineal gland

Steven L Coon, Peter J Munson, Praveen F Cherukuri, David Sugden, Martin Fredensborg Rath, Morten Møller, Samuel J H Clokie, Cong Fu, Mary E Olanich, Zoila Rangel, Thomas Werner, NISC Comparative Sequencing Program, James C Mullikin, David C Klein

58 Citations (Scopus)

Abstract

Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.

Original language	English
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	109
Issue number	33
Pages (from-to)	13319-13324
Number of pages	6
ISSN	0027-8424
DOIs	https://doi.org/10.1073/pnas.1207748109
Publication status	Published - 14 Aug 2012

Keywords

Animals
Bucladesine
Circadian Rhythm
Computational Biology
Gene Expression Regulation
Nervous System
Norepinephrine
Pineal Gland
RNA, Untranslated
Rats
Rats, Sprague-Dawley
Synapses

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Coon, S. L., Munson, P. J., Cherukuri, P. F., Sugden, D., Rath, M. F., Møller, M., Clokie, S. J. H., Fu, C., Olanich, M. E., Rangel, Z., Werner, T., NISC Comparative Sequencing Program, Mullikin, J. C., & Klein, D. C. (2012). Circadian changes in long noncoding RNAs in the pineal gland. Proceedings of the National Academy of Sciences of the United States of America, 109(33), 13319-13324. https://doi.org/10.1073/pnas.1207748109

Coon, SL, Munson, PJ, Cherukuri, PF, Sugden, D, Rath, MF , Møller, M, Clokie, SJH, Fu, C, Olanich, ME, Rangel, Z, Werner, T, NISC Comparative Sequencing Program, Mullikin, JC & Klein, DC 2012, 'Circadian changes in long noncoding RNAs in the pineal gland', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 33, pp. 13319-13324. https://doi.org/10.1073/pnas.1207748109

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abstract = "Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.",

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AU - Møller, Morten

AU - Clokie, Samuel J H

AU - Fu, Cong

AU - Olanich, Mary E

AU - Rangel, Zoila

AU - Werner, Thomas

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AU - Mullikin, James C

AU - Klein, David C

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AB - Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.

KW - Animals

KW - Bucladesine

KW - Circadian Rhythm

KW - Computational Biology

KW - Gene Expression Regulation

KW - Nervous System

KW - Norepinephrine

KW - Pineal Gland

KW - RNA, Untranslated

KW - Rats

KW - Rats, Sprague-Dawley

KW - Synapses

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DO - 10.1073/pnas.1207748109

M3 - Journal article

C2 - 22864914

SN - 0027-8424

VL - 109

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EP - 13324

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

Circadian changes in long noncoding RNAs in the pineal gland

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Keywords

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