Circadian changes in long noncoding RNAs in the pineal gland

Steven L Coon; Peter J Munson; Praveen F Cherukuri; David Sugden; Martin Fredensborg Rath; Morten Møller; Samuel J H Clokie; Cong Fu; Mary E Olanich; Zoila Rangel; Thomas Werner; NISC Comparative Sequencing Program; James C Mullikin; David C Klein

doi:10.1073/pnas.1207748109

Circadian changes in long noncoding RNAs in the pineal gland

Steven L Coon, Peter J Munson, Praveen F Cherukuri, David Sugden, Martin Fredensborg Rath, Morten Møller, Samuel J H Clokie, Cong Fu, Mary E Olanich, Zoila Rangel, Thomas Werner, NISC Comparative Sequencing Program, James C Mullikin, David C Klein

58 Citationer (Scopus)

Abstract

Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.

Originalsprog	Engelsk
Tidsskrift	Proceedings of the National Academy of Sciences of the United States of America
Vol/bind	109
Udgave nummer	33
Sider (fra-til)	13319-13324
Antal sider	6
ISSN	0027-8424
DOI	https://doi.org/10.1073/pnas.1207748109
Status	Udgivet - 14 aug. 2012

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10.1073/pnas.1207748109

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Coon, S. L., Munson, P. J., Cherukuri, P. F., Sugden, D., Rath, M. F., Møller, M., Clokie, S. J. H., Fu, C., Olanich, M. E., Rangel, Z., Werner, T., NISC Comparative Sequencing Program, Mullikin, J. C., & Klein, D. C. (2012). Circadian changes in long noncoding RNAs in the pineal gland. Proceedings of the National Academy of Sciences of the United States of America, 109(33), 13319-13324. https://doi.org/10.1073/pnas.1207748109

Coon, SL, Munson, PJ, Cherukuri, PF, Sugden, D, Rath, MF , Møller, M, Clokie, SJH, Fu, C, Olanich, ME, Rangel, Z, Werner, T, NISC Comparative Sequencing Program, Mullikin, JC & Klein, DC 2012, 'Circadian changes in long noncoding RNAs in the pineal gland', Proceedings of the National Academy of Sciences of the United States of America, bind 109, nr. 33, s. 13319-13324. https://doi.org/10.1073/pnas.1207748109

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title = "Circadian changes in long noncoding RNAs in the pineal gland",

abstract = "Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.",

keywords = "Animals, Bucladesine, Circadian Rhythm, Computational Biology, Gene Expression Regulation, Nervous System, Norepinephrine, Pineal Gland, RNA, Untranslated, Rats, Rats, Sprague-Dawley, Synapses",

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AU - Coon, Steven L

AU - Munson, Peter J

AU - Cherukuri, Praveen F

AU - Sugden, David

AU - Rath, Martin Fredensborg

AU - Møller, Morten

AU - Clokie, Samuel J H

AU - Fu, Cong

AU - Olanich, Mary E

AU - Rangel, Zoila

AU - Werner, Thomas

AU - NISC Comparative Sequencing Program

AU - Mullikin, James C

AU - Klein, David C

PY - 2012/8/14

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N2 - Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.

AB - Long noncoding RNAs (lncRNAs) play a broad range of biological roles, including regulation of expression of genes and chromosomes. Here, we present evidence that lncRNAs are involved in vertebrate circadian biology. Differential night/day expression of 112 lncRNAs (0.3 to >50 kb) occurs in the rat pineal gland, which is the source of melatonin, the hormone of the night. Approximately one-half of these changes reflect nocturnal increases. Studies of eight lncRNAs with 2- to >100-fold daily rhythms indicate that, in most cases, the change results from neural stimulation from the central circadian oscillator in the suprachiasmatic nucleus (doubling time = 0.5-1.3 h). Light exposure at night rapidly reverses (halving time = 9-32 min) levels of some of these lncRNAs. Organ culture studies indicate that expression of these lncRNAs is regulated by norepinephrine acting through cAMP. These findings point to a dynamic role of lncRNAs in the circadian system.

KW - Animals

KW - Bucladesine

KW - Circadian Rhythm

KW - Computational Biology

KW - Gene Expression Regulation

KW - Nervous System

KW - Norepinephrine

KW - Pineal Gland

KW - RNA, Untranslated

KW - Rats

KW - Rats, Sprague-Dawley

KW - Synapses

U2 - 10.1073/pnas.1207748109

DO - 10.1073/pnas.1207748109

M3 - Journal article

C2 - 22864914

SN - 0027-8424

VL - 109

SP - 13319

EP - 13324

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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ER -

Circadian changes in long noncoding RNAs in the pineal gland

Abstract

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