Chewing gum and lozenges as delivery systems for noscapine

L. Norgaard Jensen; Lona Louring Christrup; N. Menger; H. Bundgaard

Chewing gum and lozenges as delivery systems for noscapine

L. Norgaard Jensen, Lona Louring Christrup, N. Menger, H. Bundgaard

13 Citations (Scopus)

Abstract

Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.

Original language	English
Journal	Acta Pharmaceutica Nordica
Volume	3
Issue number	4
Pages (from-to)	219-222
Number of pages	4
ISSN	1100-1801
Publication status	Published - 1 Jan 1991

Cite this

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abstract = "Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.",

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T1 - Chewing gum and lozenges as delivery systems for noscapine

AU - Norgaard Jensen, L.

AU - Christrup, Lona Louring

AU - Menger, N.

AU - Bundgaard, H.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.

AB - Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.

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SN - 1100-1801

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SP - 219

EP - 222

JO - Acta Pharmaceutica Nordica

JF - Acta Pharmaceutica Nordica

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ER -

Chewing gum and lozenges as delivery systems for noscapine

Abstract

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