TY - JOUR
T1 - Chewing gum and lozenges as delivery systems for noscapine
AU - Norgaard Jensen, L.
AU - Christrup, Lona Louring
AU - Menger, N.
AU - Bundgaard, H.
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.
AB - Chewing gum and lozenges were evaluated as delivery systems for noscapine with the aim of developing improved antitussive preparations. The formulations studied were prepared with both the water-soluble hydrochloride salt of noscapine and with the poorly soluble embonate salt and noscapine free base. The release characteristics of the preparations were evaluated both in vitro and in vivo, and their taste properties examined. Only the formulations containing noscapine base were without any appreciable taste. Chewing gum containing this compound showed, however, a low level of drug release both in vitro and in vivo and is therefore not a suitable dosage form. Only a lozenge formulation containing noscapine base fulfilled the requirements of taste acceptability and adequate release properties.
UR - http://www.scopus.com/inward/record.url?scp=0026343463&partnerID=8YFLogxK
M3 - Journal article
AN - SCOPUS:0026343463
SN - 1100-1801
VL - 3
SP - 219
EP - 222
JO - Acta Pharmaceutica Nordica
JF - Acta Pharmaceutica Nordica
IS - 4
ER -