Abstract
An overview of the chemical and photochemical probes which over the past ten years have been used in studies of DNA/ligand complexes and of non-B-form DNA conformations is presented with emphasis on the chemical reactions of the probes with DNA and on their present 'use-profile'. The chemical probes include: dimethyl sulfate, ethyl nitroso urea, diethyl pyrocarbonate, osmium tetroxide, permanganate, aldehydes, methidiumpropyl-EDTA-Fell (MPE), phenanthroline metal complexes and EDTA/FeII. The photochemical probes that have been used include: psoralens, UVB, acridines and uranyl salts. The biological systems analysed by use of these probes are reviewed by tabulation.
| Original language | English |
|---|---|
| Journal | Journal of Molecular Recognition |
| Volume | 3 |
| Issue number | 1 |
| Pages (from-to) | 1-25 |
| Number of pages | 25 |
| ISSN | 0952-3499 |
| DOIs | |
| Publication status | Published - Feb 1990 |
Keywords
- DNA
- Indicators and Reagents
- Models, Molecular
- Molecular Probes
- Nucleic Acid Conformation
- Photochemistry